The relation of one-hour postloade plasma glucose with inflammatory factor TNF-α and Hs-CRP in different glucose tolerance

LI Ying; et al

doi:10.13406/j.cnki.cyxb.2011.01.015

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The relation of one-hour postloade plasma glucose with inflammatory factor TNF-α and Hs-CRP in different glucose tolerance

更新时间：2024-01-17

- The relation of one-hour postloade plasma glucose with inflammatory factor TNF-α and Hs-CRP in different glucose tolerance
- Journal of Chongqing Medical University Vol. 36, Issue 1, Pages: 76-79(2011)
- 作者机构：
  
  1. 重庆市红十字会医院内科
  2. 重庆医科大学附属第二医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.01.015
  CLC： R587.1
- Published：2011，
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[1]李颖,刘东方,刘军.不同糖耐量人群负荷后1h血糖与炎症因子TNF-α和Hs-CRP的关系[J].重庆医科大学学报,2011,36(01):76-79.

LI Ying, et al. The relation of one-hour postloade plasma glucose with inflammatory factor TNF-α and Hs-CRP in different glucose tolerance. [J]. Journal of Chongqing Medical University 36(1):76-79(2011)
[1]李颖,刘东方,刘军.不同糖耐量人群负荷后1h血糖与炎症因子TNF-α和Hs-CRP的关系[J].重庆医科大学学报,2011,36(01):76-79. DOI： 10.13406/j.cnki.cyxb.2011.01.015.

LI Ying, et al. The relation of one-hour postloade plasma glucose with inflammatory factor TNF-α and Hs-CRP in different glucose tolerance. [J]. Journal of Chongqing Medical University 36(1):76-79(2011) DOI： 10.13406/j.cnki.cyxb.2011.01.015.

摘要

目的:探讨不同糖耐量人群负荷后1h血糖与炎症因子的关系。方法:受试者分为4组:2型糖尿病（Type 2 diabetes mellitus

T2DM）组

糖耐量减低（Impaired glucose toleranceI

GT）组

正常糖耐量（Normal glucose tolerance

NGT）组;在NGT人群中取口服葡萄糖耐量试验（Oral glucose tolerance test

OGTT）糖负荷后1 h血糖（One hour plasma glucose after glucose load

1 hPG）值为8.0 mmol/L将其分为两组

OGTT1 h血糖正常组和OGTT1 h血糖高组。比较各组一般情况和超敏C反应蛋白（Supersensitivity C reactive protein

Hs-CRP）及肿瘤坏死因子-α（Tumor necrosis factor-α

TNF-α）。结果:（1）从1 h血糖正常组到糖尿病组TNF-α、Hs-CRP呈上升趋势

两者在1 h血糖高组介于1 h血糖正常组和IGT组之间

其中1 h血糖高组TNF-α和Hs-CRP高于1 h血糖正常组（P<0.01和P<0.05）

与IGT组差别无意义（P>0.05）。（2）1 h血糖与TNF-α、甘油三酯（Triglyeride

TG）、收缩压（Systolic blood pressure

SBP）、HsCRP呈正相关（r=0.405r;=0.388r;=0.310;均P<0.01r

=0.183;P<0.05）

与高密度脂蛋白胆固醇（High-density lipoprotein cholesterol

HDL-C）呈负相关（r=-0.302;P<0.01）。其中SBP、HDL-C、TG与1 h血糖的相关性比2 h强。（3）多元线性逐步回归分析表明TG、TNF-α和SBP分别是影响1 h血糖水平的相关因素。结论:在NGT人群中当负荷后1 h血糖高于8.0 mmol/L时有炎症因子TNF-α、Hs-CRP的改变

提示可能存在慢性炎症反应

可能与IGT或糖尿病及血管病变的发生有关

在糖尿病高危患者的筛查中不能忽略这部分人群。

Abstract

Objective:To investigate the relationship of one-hour postloade plasma glucose with inflammatory factor in different glucose tolerance.Methods:the subjects were divided into four groups:type 2 diabetes(T2DM)

impaired glucose tolerance(IGT)

normal glucose tolerance(NGT) with 1 hPG higher than 8.0 mmol/L and normal glucose tolerance with 1 hPG lower than 8.0 mmol/L.Compare the general data and Hs-CRP、TNF-α in each group.Results:(1)TNF-α and Hs-CRP were upgraded from NGT to T2DM.The levels of TNF-α and Hs-CRP in NGT which 1 hPG exceeding 8.0 mmol/L were significantly higher than that in NGT with 1 hPG lower than 8.0 mmol/L(P<0.01and P<0.05) and similar with IGT(P>0.05).(2) 1 hPG were positively correlated with TNF-α、TG、 SBP、 HsCRP

(r=0.405;r=0.388;r=0.310;all P<0.01

r=0.183;P<0.05)and negatively with HDL-C(r=-0.302;P<0.01).The correlation of SBP、HDL-C and TG with 1 hPG were harder than that with 2 hPG.(3) Multiple regression analysis showed that TG、TNF-α and SBP were independent related factors influencing 1 hPG.Conclusion:There were the change of Hs-CRP and TNF-α of inflammatory factors and there maybe the presence of abnormal inflammatory reaction in normal glucose tolerance when 1 hPG exceed 8.0 mmol/L

which is correlated with development of IGT or diabetes and vascular lesion and we can’t ignore them when we screen the population inclinable to diabetes.

关键词

负荷后1h血糖超敏C反应蛋白肿瘤坏死因子-α

Keywords

one-hour postloade plasma glucosesupersensitivity C reactive proteintumor necrosis factor-α

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