The clinical experience of Doxepin for adjuvant treatment of bronchial asthma

YU Tian; et al

doi:10.13406/j.cnki.cyxb.2011.01.013

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The clinical experience of Doxepin for adjuvant treatment of bronchial asthma

更新时间：2024-01-17

- The clinical experience of Doxepin for adjuvant treatment of bronchial asthma
- Journal of Chongqing Medical University Vol. 36, Issue 1, Pages: 103-105(2011)
- 作者机构：
  
  1. 成都市第六人民医院呼吸科
  2. 成都市第四人民医院内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.01.013
  CLC： R562.25
- Published：2011，
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[1]余阗,李慧,李伟铭.多塞平辅助治疗支气管哮喘的临床观察[J].重庆医科大学学报,2011,36(01):103-105.

YU Tian, et al. The clinical experience of Doxepin for adjuvant treatment of bronchial asthma. [J]. Journal of Chongqing Medical University 36(1):103-105(2011)
[1]余阗,李慧,李伟铭.多塞平辅助治疗支气管哮喘的临床观察[J].重庆医科大学学报,2011,36(01):103-105. DOI： 10.13406/j.cnki.cyxb.2011.01.013.

YU Tian, et al. The clinical experience of Doxepin for adjuvant treatment of bronchial asthma. [J]. Journal of Chongqing Medical University 36(1):103-105(2011) DOI： 10.13406/j.cnki.cyxb.2011.01.013.

摘要

目的:探讨临床使用多塞平缓解支气管哮喘患者的焦虑、抑郁情绪

对支气管哮喘发作治疗的影响。方法:53例支气管哮喘患者随机分为对照组（n=25）和治疗组（n=28）

2组均予以相应的解痉平喘、抗炎治疗

治疗组同时予以多塞平25 mg/次

每日2次

疗程2～3周。治疗前后分别测定用力肺活量（Forced vital capacity

FVC）、第1 s末用力呼气量（Forced expiratory volumeat 1st s

FEV1）预计值%和呼气流量峰值（Peak expiratory flow

PEF）的变化;采用医院焦虑抑郁量表（Hospital anxiety and depressionscale

HAD）评估患者焦虑抑郁情绪。结果:2组哮喘症状、体征均有明显改善

但治疗组主诉及住院期间发作次数较对照组明显减少（P<0.05）。治疗组FEV1%、PEF值改善显著高于对照组。治疗组HAD评分明显改善（P<0.05）。结论:支气管哮喘是一种以气道慢性炎症和高反应性为特征的身心疾病

心理情绪因素在哮喘发病和控制中起着重要作用

多塞平作为一种哮喘的辅助治疗能明显改善支气管哮喘患者的发作和肺功能。

Abstract

Objective:To investigate the effect of Doxepine in treating bronchial asthma attack through the remission of anxiety and depresstion in clinic.Methods:53 patients with bronchial asthma were randomly allocated into two groups

Doxepine treatment group(28 cases) and control group(25 cases).The relieving asthma and anti-inflammatory therapy was given in both groups and those patients in the treatment group were administrated with Doxepine 25mg twice a day for 2 to 3 weeks.In addition

force volume capacity(FVC)

the percent value of the first second of forced expiratory volume(FEV1%) and the change of peak expiratory flow(PEF) were determined before and after therapy.The anxiety and depression scores in those asthma patients were evaluated by the hospital anxiety depression scale(HAD).Results:Asthma symptoms and physical signs in the two groups were obviously improved.However

the chief complaint and attack frequency in the treatment group were decreased significantly compared with those in the control group(P<0.05).Further more

the values of FEV1% and PEF in the treatment group were higher than those in the control group and HAD score in the treatment group was apparently improved(P<0.05).Conclusion:Bronchial asthma is a psychosomatic disease characterized by airway responsiveness inflammation and airway hyperresponsiveness.Psychological and emotional factors play an important part in asthma attack and control.Doxepine as an adjunctive therapy for asthma may obviously improve asthma attack and pulmonary function in the bronchial asthma patients.

关键词

支气管哮喘多塞平肺功能

Keywords

bronchial asthmadoxepinelung function

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