Assessment of the relationship between hyperuricemia and left ventricular diastolic function in elderly patients with hypertension with or without hyperuricemia

ZHUANG Ping; et al

doi:10.13406/j.cnki.cyxb.2011.01.010

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Assessment of the relationship between hyperuricemia and left ventricular diastolic function in elderly patients with hypertension with or without hyperuricemia

更新时间：2024-01-17

- Assessment of the relationship between hyperuricemia and left ventricular diastolic function in elderly patients with hypertension with or without hyperuricemia
- Journal of Chongqing Medical University Vol. 36, Issue 1, Pages: 83-87(2011)
- 作者机构：
  
  1. 四川省林业中心医院内一科
  2. 解放军成都军区总医院干部病房
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.01.010
  CLC： R544.1
- Published：2011，
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[1]庄苹,许婷媛,常彬宾,肖欣荣.高尿酸血症与老年高血压患者左心室舒张功能的相关性研究[J].重庆医科大学学报,2011,36(01):83-87.

ZHUANG Ping, et al. Assessment of the relationship between hyperuricemia and left ventricular diastolic function in elderly patients with hypertension with or without hyperuricemia. [J]. Journal of Chongqing Medical University 36(1):83-87(2011)
[1]庄苹,许婷媛,常彬宾,肖欣荣.高尿酸血症与老年高血压患者左心室舒张功能的相关性研究[J].重庆医科大学学报,2011,36(01):83-87. DOI： 10.13406/j.cnki.cyxb.2011.01.010.

ZHUANG Ping, et al. Assessment of the relationship between hyperuricemia and left ventricular diastolic function in elderly patients with hypertension with or without hyperuricemia. [J]. Journal of Chongqing Medical University 36(1):83-87(2011) DOI： 10.13406/j.cnki.cyxb.2011.01.010.

摘要

目的:研究老年高血压人群高尿酸血症（Hyperuricemia

HU）和左心室舒张功能不全的发生情况

以及二者之间的相关性。方法:纳入高血压病人共321例

根据血尿酸（Uric acid

UA）的浓度分为高尿酸血症组[HU（+）]和尿酸正常组[HU（-）]。比较2组TC、TG、HDL-C、LDL-C、空腹血糖、血清肌酐、血UA、心脏彩色多普勒超声检查心脏舒张和收缩功能指标;进行多因素相关性分析HU与左心室舒张功能之间的相关性。结果:①纳入的高血压人群中HU的发病率为30.5%;纳入人群中左心室舒张功能不全患者占80.7%

左心室舒张功能不全患者中HU患者占33.2%。②HU（+）组与HU（-）组相比左心室舒张功能不全患者比例升高

差异有统计学意义;HU（+）组血清NT-proBNP浓度高于HU（-）组。③经过多因素线性回归分析、Pearson和Sperman相关性分析显示UA与室间隔厚度（IVS）、左心室后壁厚度（LVPW）、舒张晚期二尖瓣环运动速度（Am）、氮末端标记的脑型尿钠肽前体（NT-proBNP）呈正相关;尿酸和舒张早期二尖瓣根部运动速度（Em）、舒张早期二尖瓣根部运动速度/舒张晚期二尖瓣根部运动速度（Em/Am）、舒张早期二尖瓣血流峰值/舒张晚期二尖瓣血流峰值（Emv/Amv）呈负相关。结论:①老年高血压人群中HU发生率和左心室舒张功能不全发生率高;②HU是左心室舒张功能不全的影响因素

反映左心室舒张功能不全的指标NT-proBNP在HU引发的左心室舒张功能不全的诊断中同样有价值。

Abstract

Objective:To investigate the characteristics of hypertension

left ventricular diastolic dysfunction and the relationship between heart diastolic dysfunction and hyperuricemia in the elderly patients with hypertension.Methods:Three hundred and twenty one hospitalized elderly patients with hypertension in the department of geriatrics were involved in this study.Among them ninety eight patients were diagnosed as hyperuricemia and two hundred and twenty three were not.Blood biochemical parameters and clinical medical histories were compared between the two groups;a multipe regression analysis between left ventricular diastolic function and hyperuricemia was conducted.Results:①The prevalence of hyperuricemia in the elderly patients with hypertension was 30.5%

and the prevalence of heart diastolic was dysfunction 87.0%.②Compared with HU(-) group

HU(+) group had increased NT-proBNP and higher prevalence of left ventricular dysfunction.③A multiple regression analysis and pearson correspondence analysis showed that uric acid had positive correlation with IVS

LVPW

Am and NT-proBNP

and negative correlation with Em

Emv/Amv

and Em/Am.Conclusion:①There is high prevalence of hyperteruricemia and left ventricular dysfunction in elderly patients with hypertension in our research

and the prevalece of left ventricular dysfunction in females were higher than that in nale.②Abnormal concentration of uric acid is the main factor in the process of left ventricular dysfunction.Even in the patients of diastolic damage caused by hyperuricemia

NT-proBNP is also a diadynamic criterion.

关键词

高血压高尿酸血症左心室舒张功能

Keywords

hypertensionhyperuricemialeft ventricular function

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