The variance analysis and multiple linear regression analysis for 16 cardiovascular disease predisposing gene SNPs and plasma lipoproteins in male Chinese Han’s population

CAI Xiao-zhong; et al

doi:10.13406/j.cnki.cyxb.2011.01.009

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The variance analysis and multiple linear regression analysis for 16 cardiovascular disease predisposing gene SNPs and plasma lipoproteins in male Chinese Han’s population

更新时间：2024-01-17

- The variance analysis and multiple linear regression analysis for 16 cardiovascular disease predisposing gene SNPs and plasma lipoproteins in male Chinese Han’s population
- Journal of Chongqing Medical University Vol. 36, Issue 1, Pages: 35-37(2011)
- 作者机构：
  
  1. 重庆医科大学医学检验系实验诊断教研室
  2. 重庆医科大学公共卫生学院流行病学教研室
  3. 深圳市人民医院临床研究中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2011.01.009
  CLC： R54
- Published：2011，
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[1]蔡晓钟,唐晓君,戴勇,唐敏.心血管疾病易感基因SNPs对中国汉族男性人群血脂的影响分析[J].重庆医科大学学报,2011,36(01):35-37.

CAI Xiao-zhong, et al. The variance analysis and multiple linear regression analysis for 16 cardiovascular disease predisposing gene SNPs and plasma lipoproteins in male Chinese Han’s population. [J]. Journal of Chongqing Medical University 36(1):35-37(2011)
[1]蔡晓钟,唐晓君,戴勇,唐敏.心血管疾病易感基因SNPs对中国汉族男性人群血脂的影响分析[J].重庆医科大学学报,2011,36(01):35-37. DOI： 10.13406/j.cnki.cyxb.2011.01.009.

CAI Xiao-zhong, et al. The variance analysis and multiple linear regression analysis for 16 cardiovascular disease predisposing gene SNPs and plasma lipoproteins in male Chinese Han’s population. [J]. Journal of Chongqing Medical University 36(1):35-37(2011) DOI： 10.13406/j.cnki.cyxb.2011.01.009.

摘要

目的:了解中国汉族男性人群中16个心血管疾病易感基因SNPs与血脂的关系。方法:采用基因芯片技术和单因素方差、多元线性逐步回归方法

分析409例男性体检者16个SNPs的基因型

同时测定其血浆总胆固醇（Total cholesterol

TC）、甘油三酯（Triglyceride

TG）、低密度脂蛋白（Low-density lipoprotein

LDL）和高密度脂蛋白（High density lipoprotein

HDL）水平。结果:在中国汉族男性人群中

ANP2238C、NPRC-55C、ApoBEcorⅠ+、ApoC33206T和ApoE112

158的E3E4

Serpina3rs4943 AG有升高TC趋势;ApoC33206T和MTHFR677C亦可能与TG增高相关;ANP2238C、ET-2985G和ApoE112

158E3E4则与LDL水平增高有一定联系;ET-2985A则可能使HDL增高。结论:内皮系统相关的ANP2 238、NPRC-55和ET-2985

载脂蛋白基因中的ApoBEcorⅠ、ApoC33175、ApoC33206和ApoE112

158

以及MTHFR677和SerpinA3rs4934等9个SNPs可能与中国汉族男性的血脂调控有关。

Abstract

Objective:To learn the association between 16 SNPs of 12 cardiovascular disease predisposing genes and the levels of blood TC

LDL and HDL in male Chinese Han’s population.Methods:The 16 SNPs genotypes of 409 Han male whose native places were almost over the mainland of China were detected.The relationships between the SNPs and blood TC

LDL and HDL were analyzed with variance analysis and multiple linear regression analysis.Results:Variance analysis and/or multiple linear regression showed that:ANP2 238C

NPRC-55C

ApoBEcorⅠ+

ApoC33 206

ApoE112

158E3E4 and Serpina3rs4 943 AG were associated with the elevation of TC;ApoC33 206T and MTHFR677C might have related with TG elevation;ANP2 238C

ET-2985G and ApoE112

158E3E4 might increase the level of blood LDL.ET-2985 A could increase the value of HDL.Conclusions:In male Chinese Han’s population

ANP2 238

NPRC-55

ET-2985

ApoBEcorⅠ

ApoC33 175

ApoC33 206

ApoE112

158

MTHFR677 and SerpinA3rs4 934 could influence the regulation of plasma lipoprotein.

关键词

单核苷酸多态性基因芯片血浆脂蛋白

Keywords

polymorphism single nucleotideoligonucleotide array sequence analysisplasma lipoprotein

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