Objective:To evaluate the main performance for four types of POCT blood glucose meters.Methods:Fresh heparinized blood samples with high

medium

low glucose concentration were detected by four types of POCT blood glucose meters(Johnson & Johnson

Roche

Abbott

and Reiter).The degree of precision

the rate of recovery

linearity

interference

and hematocrit effect for the four types of blood glucose meters were evaluated.The results of venous blood glucose determined by biochemical analyzer and the results of venous blood

finger blood of blood glucose meter were compared.Results:Degree of precision for four detecting systems meets the requirement(CV<10%);all the rates of recovery are in the scope of 90%～110%.The linearity of Roche blood glucose meter is the best of all with high ability of anti-hemoglobin effect

but influenced greatly by ascorbic acid.Hematocrit has less impact on Roche blood glucose meters

while in the other three types of blood glucose meters

it is significantly reduced with the increase of hematocrit reading.The measured results of Johnson & Johnson

Roche

Abbott blood glucose meter are affected by galactose and xylose respectively.The results of other three types of blood glucose meters are higher than the result of biochemical analyzer(P<0.05) except for Reiter blood glucose meters.Results of finger blood glucose determination by Abbott blood glucose meters are higher than the result of venous blood glucose determination by biochemical analyzer(P<0.05)

but no difference was found with other three types of meters.Bilirubin

triglycerides

fructose

maltose

sucrose have no significant effect on the result of blood glucose as tested by four kinds of blood glucose meters.Conclusion:There are limitations for detection performance of four types POCT glucose meters.Sufficient attention should be paid in clinical monitoring of blood glucose levels for patients.Thus fully understand their characteristics in order to better prevent and treat diabetes in guidance.