The effects of rosiglitazone on the expressions of NF-κB and COX-2 in rats with focal cerebral ischemia/reperfusion injury

LI Yan; et al

doi:10.13406/j.cnki.cyxb.2010.12.044

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The effects of rosiglitazone on the expressions of NF-κB and COX-2 in rats with focal cerebral ischemia/reperfusion injury

更新时间：2024-01-17

- The effects of rosiglitazone on the expressions of NF-κB and COX-2 in rats with focal cerebral ischemia/reperfusion injury
- Journal of Chongqing Medical University Vol. 35, Issue 12, Pages: 1810-1813(2010)
- 作者机构：
  
  1. 辽宁医学院研究生学院
  2. 辽宁省锦州市中心医院神经内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.12.044
  CLC： R965
- Published：2010，
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[1]李岩,王东玉.罗格列酮对局灶性脑缺血再灌注后NF-κB和COX-2表达的影响[J].重庆医科大学学报,2010,35(12):1810-1813.

LI Yan, et al. The effects of rosiglitazone on the expressions of NF-κB and COX-2 in rats with focal cerebral ischemia/reperfusion injury. [J]. Journal of Chongqing Medical University 35(12):1810-1813(2010)
[1]李岩,王东玉.罗格列酮对局灶性脑缺血再灌注后NF-κB和COX-2表达的影响[J].重庆医科大学学报,2010,35(12):1810-1813. DOI： 10.13406/j.cnki.cyxb.2010.12.044.

LI Yan, et al. The effects of rosiglitazone on the expressions of NF-κB and COX-2 in rats with focal cerebral ischemia/reperfusion injury. [J]. Journal of Chongqing Medical University 35(12):1810-1813(2010) DOI： 10.13406/j.cnki.cyxb.2010.12.044.

摘要

目的:探讨罗格列酮对大鼠局灶性脑缺血再灌注后脑组织表达核因子-κB（Nuclear factor-κB

NF-κB）和环氧化酶2（Cyclooxygenase

COX-2）的影响。方法:SD大鼠分为假手术组、模型组、2个剂量的罗格列酮组[2 mg/（kg.d）和4 mg/（kg.d）]

测定各组脑梗死体积和缺血侧皮层NF-κB和COX-2蛋白空间分布和含量的变化。结果:与模型组比较

罗格列酮组脑梗死体积明显减少

且不同剂量组间脑梗死体积有显著差异（P<0.05）;缺血侧皮层NF-κB和COX-2蛋白表达量明显减少

且2个不同剂量组间有显著差异（P<0.05）。结论:罗格列酮通过降低缺血侧皮层NF-κB和COX-2蛋白表达减小局灶性脑缺血再灌注大鼠脑梗死体积

对缺血再灌注损伤可能具有神经保护作用。

Abstract

Objective:To investigate the effects of rosiglitazone on the expressions of NF-κB and COX-2 in rats with focal cerebral ischemia/reperfusion injury.Methods:SD rats were randomly divided into four groups:sham group

model group

low-dose(2 mg/(kg·d)) and high-dose(4mg/(kg·d)) rosiglitazone group.Infarct volume and the expressions of NF-κB and COX-2 protein were measured in the rat brain.Results:Compared with the model group

rosiglitazone reduced the cerebral infarction volume significantly(P<0.05)

and the effect of high-dose was more predominant than that of low-dose(P<0.05).Rosiglitazone also decreased the expressions of NF-κB and COX-2 protein greatly(P<0.05)

and high-dose group showed significant difference with low-dose group(P<0.05).Conclusion:Rosiglitazone can significantly reduce the infarct volume and the expressions of NF-κB and COX-2 in rats with focal cerebral ischemia/reperfusion injury.Rosiglitazone has a neuroprotective effect on cerebral ischemia/reperfusion injury.

关键词

罗格列酮过氧化物酶体增殖物激活受体γ核因子-κB环氧化酶2

Keywords

rosiglitazoneperoxisome proliferator-activated receptor γnuclear factor-κBCyclooxygenase 2

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