The expression and significance of eotaxin and mcp-1 in peripheral blood from patients with chronic urticaria

YUAN Qun-xia; et al

doi:10.13406/j.cnki.cyxb.2010.12.036

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The expression and significance of eotaxin and mcp-1 in peripheral blood from patients with chronic urticaria

更新时间：2024-01-17

- The expression and significance of eotaxin and mcp-1 in peripheral blood from patients with chronic urticaria
- Journal of Chongqing Medical University Vol. 35, Issue 12, Pages: 1888-1890(2010)
- 作者机构：
  
  重庆医科大学附属第一医院皮肤科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.12.036
  CLC： R758.24
- Published：2010，
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[1]袁群霞,李惠,单葵.慢性荨麻疹患者外周血eotaxin、mcp-1的表达及意义[J].重庆医科大学学报,2010,35(12):1888-1890.

YUAN Qun-xia, et al. The expression and significance of eotaxin and mcp-1 in peripheral blood from patients with chronic urticaria. [J]. Journal of Chongqing Medical University 35(12):1888-1890(2010)
[1]袁群霞,李惠,单葵.慢性荨麻疹患者外周血eotaxin、mcp-1的表达及意义[J].重庆医科大学学报,2010,35(12):1888-1890. DOI： 10.13406/j.cnki.cyxb.2010.12.036.

YUAN Qun-xia, et al. The expression and significance of eotaxin and mcp-1 in peripheral blood from patients with chronic urticaria. [J]. Journal of Chongqing Medical University 35(12):1888-1890(2010) DOI： 10.13406/j.cnki.cyxb.2010.12.036.

摘要

目的:研究嗜酸性粒细胞趋化因子（Eosinophil chemoattractant chemokinee

otaxin）

单核细胞趋化蛋白-1（Monocytechemoattractant protein-1

mcp-1）在慢性荨麻疹患者外周血的表达及其意义。方法:逆转录聚合酶链反应（Reverse transcription-polymerase reaction

RT-PCR）、酶联免疫吸附实验（Enzyme-linked immunosorbent assay

ELISA）分别检测58例慢性荨麻疹患者和39例正常对照者外周血单个核细胞eotaxin、mcp-1的mRNA和血清蛋白的表达水平。结果:①慢性荨麻疹患者外周血单个核细胞eotaxin、mcp-1的mRNA的相对表达量分别为0.664 9±0.106 7、0.499 4±0.060 8

正常对照分别为0.424 8±0.081 8、0.289 7±0.049 6

患者组血清蛋白表达分别为（450.48±222.44）pg/ml、（103.35±46.53）pg/ml

正常对照分别为（277.76±89.49）pg/ml和（53.35±34.91）pg/ml

两者mRNA和蛋白表达组间比较均有统计学意义

P均<0.001。②慢性荨麻疹患者外周血eotaxin蛋白表达与病程长短、症状评分呈正相关

P均<0.01。结论:慢性荨麻疹患者外周血eotaxin、mcp-1表达的上调及Th免疫失衡可能与其发病有关。

Abstract

Objective:To investigate the mRNA and protein expression and significance of eosinophil chemoattractant chemokine(eotaxin) and monocyte chemoattractant protein-1(mcp-1) in peripheral blood of patients with chronic urticaria.Methods:Reverse transcription-polymerase reaction(RT-PCR) and enzyme-linked immunosorbent assay(ELISA) was applied to analyzed the mRNA and protein expression respectively in peripheral blood from 58 patients with chronic urticaria and 39 healthy controls.Results:①The mRNA expression of eotaxin and mcp-1 were 0.664 9±0.106 7

0.499 4±0.060 8 respectively in patients with chronic urticaria

0.424 8±0.081 8、0.289 7±0.049 6 in healthy controls.The protein expression of eotaxin and mcp-1 in serum were(450.48±222.44) pg/ml

(103.35±46.53) pg/ml in the patients

(277.76±89.49) pg/ml and(53.35±34.91) pg/ml in the controls.Both the mRNA and protein expression of eotaxin and mcp-1 in peripheral blood in the patients was significantly higher than those in the controls(P<0.001).②There was a positive correlation(P<0.01) between the expression of eotaxin and the course、severity of the desease.Conclusion:The results suggest that the up-regulation of the eotaxin and mcp-1 might play a certain role in the pathogenesis of chronic urticaria.

关键词

荨麻疹嗜酸性粒细胞嗜碱性粒细胞EotaxinMcp-1

Keywords

urticariaeosinophilbasophilEotaxinMcp-1

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