Expression of integrin-Linked kinase and Matrix metalloprotrinase-9 and their significance in esophageal sqamous carcinoma tissues

YU Jun-long; et al

doi:10.13406/j.cnki.cyxb.2010.12.031

您当前的位置：

首页 >

文章列表页 >

Expression of integrin-Linked kinase and Matrix metalloprotrinase-9 and their significance in esophageal sqamous carcinoma tissues

更新时间：2024-01-17

- Expression of integrin-Linked kinase and Matrix metalloprotrinase-9 and their significance in esophageal sqamous carcinoma tissues
- Journal of Chongqing Medical University Vol. 35, Issue 12, Pages: 1874-1877(2010)
- 作者机构：
  
  重庆医科大学附属第一医院胸心外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.12.031
  CLC： R735.1
- Published：2010，
扫描看全文
[1]余俊隆,温剑虎.ILK和MMP9在食管鳞癌组织中的表达及其意义[J].重庆医科大学学报,2010,35(12):1874-1877.

YU Jun-long, et al. Expression of integrin-Linked kinase and Matrix metalloprotrinase-9 and their significance in esophageal sqamous carcinoma tissues. [J]. Journal of Chongqing Medical University 35(12):1874-1877(2010)
[1]余俊隆,温剑虎.ILK和MMP9在食管鳞癌组织中的表达及其意义[J].重庆医科大学学报,2010,35(12):1874-1877. DOI： 10.13406/j.cnki.cyxb.2010.12.031.

YU Jun-long, et al. Expression of integrin-Linked kinase and Matrix metalloprotrinase-9 and their significance in esophageal sqamous carcinoma tissues. [J]. Journal of Chongqing Medical University 35(12):1874-1877(2010) DOI： 10.13406/j.cnki.cyxb.2010.12.031.

摘要

目的:探讨整合素连接激酶（Integrin-linked kinaseI

LK）和基质金属蛋白酶（Matrix metallo proteinases

MMPs）在食管鳞癌组织中的表达及其与肿瘤组织分化程度原发肿瘤（Primans tumor

T）区域淋巴结（Regional lymph nodes

N）远处转移（Distant metastssis

M）分期;淋巴结转移及预后关系

分析两者是否存在相关性。方法:采用间接免疫荧光法检测45例食管鳞癌组织及20例食管正常黏膜组织中ILK和MMP-9表达情况

并结合临床和病理资料进行分析。结果:免疫荧光法结果显示:食管鳞癌组织中ILK、MMP-9阳性表达率分别为68.89%（31/45）

62.22%（28/45）

正常食管黏膜组织中ILK、MMP-9阳性表达率20%（4/20）和30%（6/20）。随着肿瘤细胞病理分级

临床分期程度增高及淋巴转移I

LK、MMP-9阳性表达率增高

各组间均有显著差异（P<0.05）

食管鳞癌组织与正常食管粘膜组织中ILK、MMP-9阳性表达比较均有显著差异（P<0.05）。Kaplan-Meier生存曲线法分析显示ILK高表达与MMP-9高表达患者生存时间明显低于ILK低表达与MMP-9低表达患者。结论I:LK、MMP-9蛋白与食管鳞癌关系密切

ILK和MMP-9在食管鳞癌组织中表达显著正相关（P<0.001）

表明ILK高表达或激活可能是MMP-9高表达或过表达原因之一。ILK可作为判断食管鳞癌患者预后的主要参考指标

联合检测ILK、MMP-9表达有助于判断食管鳞癌患者的预后。

Abstract

Objective:To investigate the expression of ILK and MMP-9 in esophageal squamous cell carcinoma and its relationship with tumor differentiation

TNM staging

lymph node metastasis and prognosis

and to understand whether there is correlation between ILK and MMP-9.Methods:The indirect immunofluorescence detection of ILK and MMP-9 expression in 45 cases of esophageal squamous cell carcinoma and 20 cases of normal esophageal mucosa were analyzed with clinical and pathological data.Results:The immunofluorescence results showed that the expression rates of ILK and MMP-9 in esophageal squamous cell carcinoma were 68.89%(31/45) and 62.22%(28/45).The positive rates of ILK and MMP-9 in normal esophageal mucosa were 20%(4/20) and 30%(6/20).As the tumor cell grade

clinical stage and lymph node metastasis increased the level of ILK and

MMP-9 expression rate increased

with significant difference among all groups(P<0.05).The positive expression of ILK

MMP-9 in esophageal squamous cell carcinoma and normal esophageal mucosa were significantly different(P <0.05).Kaplan-Meier analysis showed the survival time for patient with high expression of ILK and MMP-9 was significantly lower than that for patients with low expression of ILK and MMP-9.Conclusion:ILK

MMP-9 protein are closely related to esophageal squamous cell carcinoma

ILK expression or activation may be the reason for the high expression or over-expression of MMP-9.ILK could be used as an independent prognosis reference for esophageal squamous cell carcinoma

The joint detection of ILK and MMP-9 expression can help determine the prognosis of patients with esophageal squamous cell carcinoma.

关键词

食管癌整合素连接激酶明胶酶B免疫荧光化学

Keywords

Esophageal neoplasmsIntegrin-Linked kinaseGelatinase BImmunofluorescence

references

Views

114

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

No data

Related Author

No data

Related Institution

No data

⁰