The expressions and clinical significance of MyoD1 and myogenin in rhabdomyosarcomas of childhood

MA Yu-hong; et al

doi:10.13406/j.cnki.cyxb.2010.12.030

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The expressions and clinical significance of MyoD1 and myogenin in rhabdomyosarcomas of childhood

更新时间：2024-01-17

- The expressions and clinical significance of MyoD1 and myogenin in rhabdomyosarcomas of childhood
- Journal of Chongqing Medical University Vol. 35, Issue 12, Pages: 1870-1873(2010)
- 作者机构：
  
  重庆医科大学附属儿童医院肿瘤外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.12.030
  CLC： R738.7
- Published：2010，
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[1]马玉虹,王珊,邓晓斌,李想.MyoD1、Myogenin在儿童横纹肌肉瘤中的表达及其临床意义[J].重庆医科大学学报,2010,35(12):1870-1873.

MA Yu-hong, et al. The expressions and clinical significance of MyoD1 and myogenin in rhabdomyosarcomas of childhood. [J]. Journal of Chongqing Medical University 35(12):1870-1873(2010)
[1]马玉虹,王珊,邓晓斌,李想.MyoD1、Myogenin在儿童横纹肌肉瘤中的表达及其临床意义[J].重庆医科大学学报,2010,35(12):1870-1873. DOI： 10.13406/j.cnki.cyxb.2010.12.030.

MA Yu-hong, et al. The expressions and clinical significance of MyoD1 and myogenin in rhabdomyosarcomas of childhood. [J]. Journal of Chongqing Medical University 35(12):1870-1873(2010) DOI： 10.13406/j.cnki.cyxb.2010.12.030.

摘要

目的:探讨MyoD1、Myogenin在儿童横纹肌肉瘤（Rhabdomyosarmma

RMS）及其他3种儿童小细胞恶性肿瘤中的表达情况及其临床意义。方法:选取胚胎型横纹肌肉瘤（Embryonal rhab domyosarcoma

ERMS）11例

腺泡型横纹肌肉瘤（Alveolar rhab domyosarcoma

ARMS）5例

神经母细胞瘤、恶性淋巴瘤、尤文肉瘤各10例

行HE染色

并应用S-P免疫组织化学染色法检测MyoD1、Myogenin蛋白在这4种儿童小细胞恶性肿瘤中的表达水平。结果:MyoD1、Myogenin在RMS中阳性表达率分别为7:5%

68.75%

在其他3种肿瘤中阳性表达率均为0%

MyoD1、Myogenin在RMS组中的表达与其他肿瘤组比较差异有统计学意义（P<0.05）

2种蛋白在ARMS中的阳性表达率明显高于ERMS（P<0.05）

其恶性程度越高

MyoD1和Myogenin阳性表达越强（P<0.05）。MyoD1、Myogenin在预后差组中的阳性表达率明显高于预后中组（P<0.05）。结论:MyoD1、Myogenin可以作为辅助鉴别RMS及其他小细胞恶性肿瘤的依据;MyoD1、Myogenin基因可以作为辅助诊断儿童RMS的综合指标

也可作为鉴别儿童ERMS和ARMS有用的分子生物学标志;检测儿童RMS中MyoD1、Myogenin的表达情况对RMS恶性程度及预后的判断有一定的临床指导意义。

Abstract

Objective:To investigate the expressions of MyoD1 and Myogenin in rhabdomyosarcoma(RMS)and other small cell malignant tumors of childhood

so as to approach their clinical significance.Methods:11 cases of embryonal rhabdomyosarcoma(ERMS)

5 cases of alveolar rhabdomyosarcoma(ARMS)

10 cases of neuroblastoma

10 cases of malignant lymphoma and 10 cases of Ewing’s sarcoma were collected and stained with HE staining

to detect the expression levels of MyoD1 and Myogenin proteins by S-P immunohistochemistry method in these 4 types of small cell malignant tumors.Results:The positive expressions of MyoD1 and Myogenin in RMS were 75% and 68.75% respectively

but the expression rates in the other 3 types of small cell malignant tumors were 0%.The positive expression rates and intensity of MyoD1 and Myogenin in RMS group were higher than those in the other 3 types of small cell malignant tumors significantly(P<0.05).The positive expression rates of these 2 proteins in ARMS were higher than in ERMS(P<0.05).The higher malignant level was

the higher the positive expressions of MyoD1 and myogenin showed(P<0.05).The positive expressive rates of these 2 types of proteins in bad prognosis group were higher than those in middle prognosis group(P<0.05).Conclusion:The obvious expression difference between MyoD1 and Myogenin in RMS and in the other 3 types of small cell malignant tumors can be used as an index that distinguishes RMS with other small cell malignant tumors.MyoD1 and Myogenin can be a combination index of auxiliary diagnosis in RMS

providing significant and additional molecular biological methods to pathological diagnosis.

关键词

横纹肌肉瘤儿童MyoD1Myogenin

Keywords

RhabdomyosarmmachildMyoD1Myogenin

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