Expressions of PLGF and VEGFR-1 in invasive pituitary adenoma

ZHANG Yi; et al

doi:10.13406/j.cnki.cyxb.2010.12.027

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Expressions of PLGF and VEGFR-1 in invasive pituitary adenoma

更新时间：2024-01-17

- Expressions of PLGF and VEGFR-1 in invasive pituitary adenoma
- Journal of Chongqing Medical University Vol. 35, Issue 12, Pages: 1825-1827(2010)
- 作者机构：
  
  重庆医科大学附属第一医院神经外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.12.027
  CLC： R736.4
- Published：2010，
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[1]张毅,霍钢,冯清林,杨刚,唐茂源,贺学农.PLGF及其受体VEGFR-1在侵袭性垂体腺瘤中的表达[J].重庆医科大学学报,2010,35(12):1825-1827.

ZHANG Yi, et al. Expressions of PLGF and VEGFR-1 in invasive pituitary adenoma. [J]. Journal of Chongqing Medical University 35(12):1825-1827(2010)
[1]张毅,霍钢,冯清林,杨刚,唐茂源,贺学农.PLGF及其受体VEGFR-1在侵袭性垂体腺瘤中的表达[J].重庆医科大学学报,2010,35(12):1825-1827. DOI： 10.13406/j.cnki.cyxb.2010.12.027.

ZHANG Yi, et al. Expressions of PLGF and VEGFR-1 in invasive pituitary adenoma. [J]. Journal of Chongqing Medical University 35(12):1825-1827(2010) DOI： 10.13406/j.cnki.cyxb.2010.12.027.

摘要

目的:探讨胎盘生长因子（Placenta growth factor

PLGF）及其受体血管内皮生长因子受体-1（Vascular endothelial growth factor receptor-1

VEGFR-1）在侵袭性和非侵袭性垂体腺瘤中的表达及与垂体腺瘤侵袭发生发展的相关性。方法:收集57例垂体腺瘤手术标本

按侵袭性垂体腺瘤综合判定方法分为侵袭组和非侵袭组

采用免疫组化检测PLGF和VEGFR-1蛋白的表达

RT-PCR法检测PLGF和VEGFR-1 mRNA的表达

分析侵袭组和非侵袭组PLGF和VEGFR-1表达水平的差异。结果:57例垂体瘤患者中

30例为侵袭性垂体腺瘤

27例为非侵袭性垂体腺瘤。侵袭性垂体腺瘤组PLGF和VEGFR-1的蛋白和mRNA表达均较非侵袭性腺瘤组增高。结论:垂体腺瘤的侵袭性与PLGF和VEGFR-1蛋白及mRNA的高表达密切相关

二者可能参与侵袭性垂体腺瘤的发生及发展过程。

Abstract

Objective:To explore the expressions of PLGF(Placenta growth factor) and VEGFR-1(Vascular endothelial growth factor receptor-1) in pituitary adenoma and their relationship with the invasiveness of the adenoma.Methods:57 specimens of pituitary adenoma were classified into invasive and non-invasive group according to the comprehensive evaluation of invasive pituitary adenoma.The protein expressions of PLGF and VEGFR-1 were detected by immunohistochemical analysis and their mRNA expressions were detected by reverse transcription polymerase chain reaction(RT-PCR) in the invasive and non-invasive pituitary adenomas.Results:30 specimens of pituitary adenoma were invasive and 27 were non-invasive.The protein expressions of PLGF and VEGFR-1 were significantly higher in invasive pituitary adenomas than in non-invasive ones.Their mRNA expressions were higher in invasive pituitary adenomas too.Conclusion:The expressions of PLGF and VEGFR-1 are higher in invasive pituitary adenomas

which may relate to their invasiveness.

关键词

胎盘生长因子血管内皮生长因子受体垂体腺瘤

Keywords

PLGFVEGFR-1pituitary adenoma

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