Experimental study of Artemin on proliferation and invasion of pancreatic ductal adenocarcinoma cell line

GU Sai; et al

doi:10.13406/j.cnki.cyxb.2010.12.025

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Experimental study of Artemin on proliferation and invasion of pancreatic ductal adenocarcinoma cell line

更新时间：2024-01-17

- Experimental study of Artemin on proliferation and invasion of pancreatic ductal adenocarcinoma cell line
- Journal of Chongqing Medical University Vol. 35, Issue 12, Pages: 1814-1816(2010)
- 作者机构：
  
  重庆医科大学附属第一医院消化内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.12.025
  CLC： R735.9
- Published：2010，
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[1]古赛,黄妙兴.Artemin对体外胰腺癌细胞增殖与侵袭影响的实验研究[J].重庆医科大学学报,2010,35(12):1814-1816.

GU Sai, et al. Experimental study of Artemin on proliferation and invasion of pancreatic ductal adenocarcinoma cell line. [J]. Journal of Chongqing Medical University 35(12):1814-1816(2010)
[1]古赛,黄妙兴.Artemin对体外胰腺癌细胞增殖与侵袭影响的实验研究[J].重庆医科大学学报,2010,35(12):1814-1816. DOI： 10.13406/j.cnki.cyxb.2010.12.025.

GU Sai, et al. Experimental study of Artemin on proliferation and invasion of pancreatic ductal adenocarcinoma cell line. [J]. Journal of Chongqing Medical University 35(12):1814-1816(2010) DOI： 10.13406/j.cnki.cyxb.2010.12.025.

摘要

目的:探讨Artemin对胰腺癌细胞增殖与侵袭的影响。方法:以0、10、100ng/ml Artemin处理胰腺癌PDAC细胞株24、48、72 h后

MTT法检测其对PDAC细胞的生长抑制作用。应用Transwell小室进行人工重组基底膜（Matrigel）侵袭实验

观察胰腺癌对PDAC细胞侵袭的影响。结果:MTT实验结果表明

Artemin对PDAC-1细胞增殖有一定抑制作用

但随时间延长和药物浓度加大其抑制效应增强不显著。Artemin处理后PDAC-1细胞侵袭能力增加。结论:Artemin对胰腺癌的增殖影响不明显

但能增加癌细胞的侵袭性。

Abstract

Objective:To investigate the effect of Artemin on the proliferation and invasion of pancreatic ductal adenocarcinoma(PDAC) cell line.Methods:PANC cells were treated with 0

100 ng/ml Artemin for 24

and 72 h

respectively.Proliferation of cells were measured with MTT assay.Invasion of cells were evaluated with Transwell chamber.Results:After being treated with Artemin

the proliferation of PANC cells was slightly inhibited

but not in a time and dose-dependent manner.The invasion of PANC cells was increased.Conclusion:Artemin may not associated with proliferation in PDAC

but increased cancer cell invasion.

关键词

Artemin胰腺癌增殖侵袭

Keywords

ArteminPancreatic ductal adenocarcinomaproliferationinvasion

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Related Institution

Department of Gastrointestinal Surgery，The Third Affiliated Hospital of Zunyi Medical University/ The First People’s Hospital of Zunyi

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Department of Obstetrics and Gynecology,The First Affiliated Hospital of Chongqing Medical University

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Department of Otolaryngology,The First Affiliated Hospital of Chongqing Medical University

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