Neuropathological study of frontal lobe of schizophrenia patients

SONG An-lin; et al

doi:10.13406/j.cnki.cyxb.2010.12.020

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Neuropathological study of frontal lobe of schizophrenia patients

更新时间：2024-01-17

- Neuropathological study of frontal lobe of schizophrenia patients
- Journal of Chongqing Medical University Vol. 35, Issue 12, Pages: 1924-1927(2010)
- 作者机构：
  
  1. 重庆医科大学基础医学院法医学教研室
  2. 怀化医学高等专科学校临床医学系
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.12.020
  CLC： R749.3
- Published：2010，
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[1]宋安林,李永国,朱晓燕,李剑波.精神分裂症大脑额叶神经病理学研究[J].重庆医科大学学报,2010,35(12):1924-1927.

SONG An-lin, et al. Neuropathological study of frontal lobe of schizophrenia patients. [J]. Journal of Chongqing Medical University 35(12):1924-1927(2010)
[1]宋安林,李永国,朱晓燕,李剑波.精神分裂症大脑额叶神经病理学研究[J].重庆医科大学学报,2010,35(12):1924-1927. DOI： 10.13406/j.cnki.cyxb.2010.12.020.

SONG An-lin, et al. Neuropathological study of frontal lobe of schizophrenia patients. [J]. Journal of Chongqing Medical University 35(12):1924-1927(2010) DOI： 10.13406/j.cnki.cyxb.2010.12.020.

摘要

目的:寻找精神分裂症（Schizophrenia）大脑额叶存在的病理改变

探索精神分裂症的病因和发病机制。方法:对精神分裂症组及对照组大脑额叶取材、制片

进行显微镜观察和体视学研究

寻找其客观病理改变。结果:精神分裂症大脑额叶锥体细胞大量核固缩（外锥体细胞层为主）

神经细胞变性坏死

胶质细胞增生

卫星现象和嗜神经现象较对照组显著增加（内椎体细胞层和多形层为主）

同时伴微血管充血、密度增大和大量淀粉样小体形成。结论:精神分裂症的发病可能与大脑额叶退行性病理改变密切相关。

Abstract

Objective:To study pathological changes and the etiology existing in frontal lobes of schizophrenia group.Methods:Frontal lobes of schizophrenia and normal control group were harvested and made into paraffin sections

and microscopic and stereological methods were used to study pathological changes existing in frontal lobes.Results:In schizophrenic group

a large number of pyramidal cells condensed;nerve cells degenerated and necrosed;glial cells proliferated;a large number of amyloid corpuscles formed

and satellitosis and neuronophagia significantly increased compared with the control group.Conclusion:The pathological changes in frontal lobe may be closely related with schizophrenia.

关键词

精神分裂症发病机制神经病理体视学

Keywords

schizophreniapathogenesisNeuropathologystereology

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