Changes of super microstructure of hippocampus and expressions of Caspase-3 in epileptic rats after injection of YVAD-CHO

CHEN Bo; et al

doi:10.13406/j.cnki.cyxb.2010.12.019

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Changes of super microstructure of hippocampus and expressions of Caspase-3 in epileptic rats after injection of YVAD-CHO

更新时间：2024-01-17

- Changes of super microstructure of hippocampus and expressions of Caspase-3 in epileptic rats after injection of YVAD-CHO
- Journal of Chongqing Medical University Vol. 35, Issue 12, Pages: 1794-1797(2010)
- 作者机构：
  
  重庆医科大学附属第一医院神经外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.12.019
  CLC： R742.1
- Published：2010，
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[1]陈博,谢延风,唐文渊,石全红,詹彦.注射YVAD-CHO后癫痫大鼠海马组织细胞形态及Caspase-3表达的改变[J].重庆医科大学学报,2010,35(12):1794-1797.

CHEN Bo, et al. Changes of super microstructure of hippocampus and expressions of Caspase-3 in epileptic rats after injection of YVAD-CHO. [J]. Journal of Chongqing Medical University 35(12):1794-1797(2010)
[1]陈博,谢延风,唐文渊,石全红,詹彦.注射YVAD-CHO后癫痫大鼠海马组织细胞形态及Caspase-3表达的改变[J].重庆医科大学学报,2010,35(12):1794-1797. DOI： 10.13406/j.cnki.cyxb.2010.12.019.

CHEN Bo, et al. Changes of super microstructure of hippocampus and expressions of Caspase-3 in epileptic rats after injection of YVAD-CHO. [J]. Journal of Chongqing Medical University 35(12):1794-1797(2010) DOI： 10.13406/j.cnki.cyxb.2010.12.019.

摘要

目的:探讨癫痫大鼠单侧海马注射Caspase-3抑制剂YVAD-CHO后海马组织形态及Caspase-3表达的改变。方法:将YVAD-CHO注射入癫痫大鼠模型单侧海马

HE染色观察组织形态学变化

免疫组化法观察Caspase-3蛋白的表达及相应的改变。结果:HE染色显示

干预组1大鼠海马安蒙角（Cornu ammonis

CA）1-CA3区神经细胞胞质浓染

核固缩等改变

与模型组比较明显减少;免疫组化显示干预组1海马区Caspase-3蛋白的表达较模型组明显减少。结论:YVAD-CHO可在体内抑制大鼠海马神经元凋亡。

Abstract

Objective:To investigate the changes of super microstructure of hippocampus and expression of Caspase-3 in epileptic rats after injection of YVAD-CHO.Methods:YVAD-CHO was injected into unilateral hippocampus of rats in intervention group 1.The changes of super microstructure were studied by HE staining.The changes of expressions of Caspase-3 protein were studied by immunohistochemistry method.Results:HE staining indicated that hippocampal neurons in CA1-CA3 regions changed in rats of intervention group 1

with nerve cell cytoplasm stained thick and condense chromation in nucleus

which reduced significantly compared with mode 1 group.Immunohistochemistry indicated that the expressions of Caspase-3 protein in hippocampus highly decreased in intervention group 1 in contrast to mode 1 group.Conclusion:YVAD-CHO can reduce apoptosis of rat’s hippocampal neurons in vivo.

关键词

癫痫组织形态凋亡Caspase-3

Keywords

epilepsyMorphometricsapoptosisCaspase-3

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