Objective:To observe the inhibition effect of midazolam on emergency agitation(EA) in preschool-aged children undergoing minor oral-maxillofacial outpatient surgery with sevoflurane anesthesia to provide the basis for the rational use of medicines.Methods:40 ASAⅠchildren

aged from 2 to 5 years old

weighing 15 ～ 26 kg

were divided into 2 groups

midazolam group(group M) and control group(group C)

with 20 children in each group.The anesthetic method for 2 groups was the same

laryngeal mask airway insertion after 8% sevoflurane inhalation for 1 min

2%～ 3% sevoflurane maintenance with spontaneous respiration during operation

Midazolam 0.25 mg/kg was given via nose in group M at 10 min before the operation end;while sodium was given in group C.Both groups were suspended in the completion of surgery sevoflurane.Pediatric anesthesia emergence delirium scale(PAED) was evaluated when children regained consciousness after anesthesia and the agitation of duration

recovery time and discharge time were recorded.Results:There were no significant difference in general data between two groups.The recovery time for group M was slightly longer than that for group C(P<0.01)

but postoperative agitation time for group M was significantly shorter than that for group C(P<0.05).There was no difference in discharge time.Conclusion:Midazolam can reduce the emergency agitation duration after outpatient oral-maxillofacial surgery in preschool-aged children undergoing sevoflurane anesthesia without additive adverse drug reactions.