Combined determination of SCCA,CYFRA21-1 and CEA in bronchoalveolar lavage fluid for lung cancer diagnosis

LUO Ling; et al

doi:10.13406/j.cnki.cyxb.2010.11.040

您当前的位置：

首页 >

文章列表页 >

Combined determination of SCCA,CYFRA21-1 and CEA in bronchoalveolar lavage fluid for lung cancer diagnosis

更新时间：2024-01-17

- Combined determination of SCCA,CYFRA21-1 and CEA in bronchoalveolar lavage fluid for lung cancer diagnosis
- Journal of Chongqing Medical University Vol. 35, Issue 11, Pages: 1716-1718(2010)
- 作者机构：
  
  1. 重庆市肿瘤研究所ICU科
  2. 重庆市肿瘤研究所内镜诊疗中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.11.040
  CLC： R734.2
- Published：2010，
扫描看全文
[1]罗玲,王江红.支气管肺泡灌洗液SCCA、CYFRA21-1、CEA联合检测在肺癌诊断中的价值[J].重庆医科大学学报,2010,35(11):1716-1718.

LUO Ling, et al. Combined determination of SCCA,CYFRA21-1 and CEA in bronchoalveolar lavage fluid for lung cancer diagnosis. [J]. Journal of Chongqing Medical University 35(11):1716-1718(2010)
[1]罗玲,王江红.支气管肺泡灌洗液SCCA、CYFRA21-1、CEA联合检测在肺癌诊断中的价值[J].重庆医科大学学报,2010,35(11):1716-1718. DOI： 10.13406/j.cnki.cyxb.2010.11.040.

LUO Ling, et al. Combined determination of SCCA,CYFRA21-1 and CEA in bronchoalveolar lavage fluid for lung cancer diagnosis. [J]. Journal of Chongqing Medical University 35(11):1716-1718(2010) DOI： 10.13406/j.cnki.cyxb.2010.11.040.

摘要

目的:评价鳞状细胞癌抗原（Squamous cell carcinoma antigen

SCCA）

细胞角蛋白19片段（Cytokeratin 19 fragment

CYFRA21-1）

癌胚抗原（Carcino-embryonic antigen

CEA）联合检测在肺癌诊断中的价值。方法:选择我院2008年1～4月住院行支气管镜检查的患者共62例

其中肺癌44例

肺部良性病变者18例

肺癌患者中小细胞肺癌5例、鳞癌17例、腺癌15例、未定型肺癌5例

所有肺癌患者均为病理确诊。所有患者均行支气管肺泡灌洗

并收集支气管肺泡灌洗液（Bronchoalveolarlavage fluid

BALF）检测SCCA、CYFRA21-1、CEA。结果:肺癌组SCCA、CYFRA21-1、CEA水平均高于肺部良性病变组（P<0.01）

3项指标均随病情进展升高

其中Ⅲ、Ⅳ期肺癌患者水平高于Ⅰ、Ⅱ期患者（P<0.01）。在不同病理类型中

3种指标升高的程度不等

SCCA及CYFRA21-1水平在鳞癌显著高于腺癌和小细胞肺癌（Small cell lungcancer

SCLC）

CEA水平在腺癌显著高于鳞癌和SCLC。结论:联合检测BALF中SCCA、CYFRA21-1、CEA的水平可能在肺癌的诊断

病理类型的推断以及预后的判断中具有重要意义。

Abstract

Objective:To investigate the clinical value of combined determination of tumor markers including squamous cell carcinoma antigen(SCCA)

cytokeratin 19 fragment(CYFRA21-1)

carcino-embryonic antigen(CEA) in bronchoalveolar lavage fluid(BALF).Methods:62 cases including 44 cases of lung cancer and 18 benign lung lesion were collected from inpatients registered in our hospital from January to April in 2008.The lung cancers were pathologically diagnosed including 5 cases of small cell lung cancer

17 cases of squamous cell carcinoma

15 cases of adenocarcinoma

and 5 undetermined type lung cancer.All cases were bronchoalveolar lavaged and bronchoalveolar lavage fluid were collected to detect SCCA

CYFRA21-1

CEA.Results:The levels of the 3 tumor markers measured in BALF were much higher in lung cancer group than that in benign lung disease group(P<0.01)and they were higher in patients in stage Ⅲ and Ⅳ than those in stage Ⅰ and Ⅱ.The tumor markers increased to different degrees among the patients in various pathological types.The levels of SCCA 、CYFRA21-1 measured in BALF were much higher in squamous cell carcinoma group(P<0.01)

and the levels of CEA were much higher in adenocarcinoma group.Conclusion:The measurement of the 3 tumor markers in BALF may help the diagnosis、pathological classification and prognosis evaluation of lung cancer.

关键词

鳞状细胞癌抗原细胞角蛋白19片段癌胚抗原支气管肺泡灌洗

Keywords

Squamous cell carcinoma antigenCytokeratin 19 fragmentCarcino-embryonic antigenbronchoalveolar lavage

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Application of bronchoalveolar lavage in the treatment of severe pulmonary infection

Related Author

YING Shao-cong

et al

Related Institution

Department of Respiratory,the Second Affiliated Hospital,Chongqing Medical University

⁰