Studies of diffusion-weighted imaging in lesions and normal-appearing white matter areas of multiple sclerosis

ZENG Chun; et al

doi:10.13406/j.cnki.cyxb.2010.11.031

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Studies of diffusion-weighted imaging in lesions and normal-appearing white matter areas of multiple sclerosis

更新时间：2024-01-17

- Studies of diffusion-weighted imaging in lesions and normal-appearing white matter areas of multiple sclerosis
- Journal of Chongqing Medical University Vol. 35, Issue 11, Pages: 1702-1706(2010)
- 作者机构：
  
  重庆医科大学附属第一医院放射科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.11.031
  CLC： R744.51
- Published：2010，
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[1]曾春,李咏梅,罗天友,吕发金,欧阳羽,陈璇,王忠平.扩散加权成像在多发性硬化病灶和NAWM区中的研究[J].重庆医科大学学报,2010,35(11):1702-1706.

ZENG Chun, et al. Studies of diffusion-weighted imaging in lesions and normal-appearing white matter areas of multiple sclerosis. [J]. Journal of Chongqing Medical University 35(11):1702-1706(2010)
[1]曾春,李咏梅,罗天友,吕发金,欧阳羽,陈璇,王忠平.扩散加权成像在多发性硬化病灶和NAWM区中的研究[J].重庆医科大学学报,2010,35(11):1702-1706. DOI： 10.13406/j.cnki.cyxb.2010.11.031.

ZENG Chun, et al. Studies of diffusion-weighted imaging in lesions and normal-appearing white matter areas of multiple sclerosis. [J]. Journal of Chongqing Medical University 35(11):1702-1706(2010) DOI： 10.13406/j.cnki.cyxb.2010.11.031.

摘要

目的:研究多发性硬化（Multiplesclerosis

MS）病灶、看似正常表现脑白质（Normal appearing white matter

NAWM）区与健康志愿者脑白质区表观扩散系数（Apparent diffusion coefficient

ADC）之间的差异

并探讨ADC值与扩展残疾状态量表（Expanded disability status scales

EDSS）之间的相关性。方法:对44例复发-缓解型多发性硬化（Relapsing-remitting MS

RRMS）患者和20例健康志愿者行头颅常规磁共振成像（Magnetic resonance imaging

MRI）和扩散加权成像（Diffusion weighted imaging

DWI）扫描

分别测量急性、慢性病灶、额叶NAWM区及健康志愿者额叶白质区的平均ADC值

比较其有无统计学差异

并分析病灶ADC值与EDSS评分之间的相关性。结果:（1）所有MS病灶、额叶NAWM区和健康志愿者额叶白质区各感兴趣区（Region ofinterest

ROI）的ADC值分别为（112.02±15.16）×10-5 mm2/s、（79.33±4.83）×10-5 mm2/s和（77.32±3.55）×10-5 mm2/s

三者间均有显著统计学意义（P<0.01）;（2）急性和慢性病灶ADC值分别为（136.43±7.72）×10-5mm2/s和（110.66±3.45）×10-5 mm2/s

二者有显著统计学意义（P<0.01）;（3）慢性病灶中

T1加权图像（T1-weighted images

T1WI）呈等信号和低信号病灶ADC值分别为（102.65±4.14）×10-5 mm2/s和（128.89±6.97）×10-5 mm2/s

二者有显著统计学意义（P<0.01）。（4）MS患者病灶ADC值与EDSS评分之间无显著相关性（P>0.05）。结论:通过DWI的定量指标ADC值有助于鉴别MS患者不同期相和不同信号病灶所发生的病理改变

并能检测NAWM区的隐匿性损害。

Abstract

Objective:To study the differences of apparent diffusion coefficient(ADC) values among different lesions

normal-appearing white matter(NAWM) areas in multiple sclerosis(MS) and white matter areas in healthy volunteers

and to explore the correlation between ADC values and expanded disability status scale(EDSS) scores.Methods:44 patients with relapsing-remitting MS(RRMS) and 20 healthy volunteers underwent both conventional magnetic resonance imaging(MRI) and diffusion-weighted imaging(DWI) of brain.The mean ADC values were measured for the acute and chronic lesions

NAWM areas of MS patients and white matter areas of the controls

respectively.The statistical data were performed to determine the mean ADC value differences among various lesions of MS

and to analyze the correlation between ADC values of lesions and EDSS scores.Results:(1) The mean ADC values were(112.02±15.16)×10-5 mm2/s for all lesions

(79.33±4.83)×10-5 mm2/s for NAWM areas of MS

and(77.32±3.55)×10-5 mm2/s for white matter areas of the controls

respectively

there were significant differences(P<0.01).(2) The mean ADC of acute lesions ((136.43±7.72)×10-5 mm2/s) was significantly higher than that of chronic lesions((110.66±3.45) ×10-5 mm2/s)(P<0.01).(3)In the chronic lesions

the ADC values of isointense lesions on T1-weighted images(T1WI) were lower than that of hypointense lesions(P<0.01)

the ADC values were (102.65±4.14)×10-5 mm2/s and(128.89±6.97)×10-5 mm2/s

respectively.(4)No significant correlation was found between ADC values and EDSS scores(P>0.05).Conclusion:Quantitative ADC values are useful to identify the changes of pathology in different phases and signal lesions

and to detect the occult damage in the NAWM areas of MS patients.

关键词

多发性硬化磁共振成像扩散加权成像

Keywords

multiple sclerosismagnetic resonance imagingdiffusion weighted imaging

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