Influence of <sup>99</sup>Tc-MDP combination therapy on clinical symptoms and laboratory indexes of rheumatoid arthritis

YAN Jin; et al

doi:10.13406/j.cnki.cyxb.2010.11.018

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Influence of ⁹⁹Tc-MDP combination therapy on clinical symptoms and laboratory indexes of rheumatoid arthritis

更新时间：2024-01-17

- Influence of ⁹⁹Tc-MDP combination therapy on clinical symptoms and laboratory indexes of rheumatoid arthritis
- Journal of Chongqing Medical University Vol. 35, Issue 11, Pages: 1713-1715(2010)
- 作者机构：
  
  重庆医科大学附属第一医院中西医结合科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.11.018
  CLC： R593.22
- Published：2010，
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[1]严瑾,刘岳凤,张永如.云克联合治疗对类风湿关节炎的临床及实验室指标的影响[J].重庆医科大学学报,2010,35(11):1713-1715.

YAN Jin, et al. Influence of ⁹⁹Tc-MDP combination therapy on clinical symptoms and laboratory indexes of rheumatoid arthritis. [J]. Journal of Chongqing Medical University 35(11):1713-1715(2010)
[1]严瑾,刘岳凤,张永如.云克联合治疗对类风湿关节炎的临床及实验室指标的影响[J].重庆医科大学学报,2010,35(11):1713-1715. DOI： 10.13406/j.cnki.cyxb.2010.11.018.

YAN Jin, et al. Influence of ⁹⁹Tc-MDP combination therapy on clinical symptoms and laboratory indexes of rheumatoid arthritis. [J]. Journal of Chongqing Medical University 35(11):1713-1715(2010) DOI： 10.13406/j.cnki.cyxb.2010.11.018.

摘要

目的:观察云克（99Tc-MDP）联合甲氨蝶呤、来氟米特对类风湿关节炎的临床疗效及实验室指标的变化。方法:将57例类风湿关节炎患者随机分为两组:治疗组30例采用静脉滴注云克联合口服甲氨蝶呤、来氟米特治疗;对照组27例采用单纯口服药物治疗。观察治疗前后关节症状、实验室指标变化以及症状改善时间。结果:治疗组显效7例

有效20例

无效3例

总有效率90%

对照组显效3例

有效l5例

无效9例

总有效率66.67%

2组相比P<0.05

有统计学差异;云克组在改善晨僵、减少关节压痛数、关节肿胀数和、改善ESR、CRP等方面均有统计学差异（P<0.05～0.01）。结论:云克治疗可快速明显改善类风湿关节炎的临床症状和实验室指标

且使用安全

不良反应少。

Abstract

Objective:To observe the efficacy of 99Tc-MDP combined with MTX and LEF on rheumatoid arthritis change in laboratory indexes.Methods:57 patients with rheumatoid arthritis were randomly divided into two groups.Patients in the treated group(n=30) were given the 99Tc-MDP combined with MTX and LEF

and patients in the control group(n=27) were given oral drugs only.The joint symptoms

change of laboratory indexes and time of symptom improvement were measured in two groups before and after treatment.Results:In the treated group there were 7 excellent cases

20 effective cases

3 invalid cases

the total effective rate being 90%.In the control group there were 3 excellent cases

15 effective cases

9 invalid cases

the total effective rate being 66.67%.There were statistically significant difference between the two groups(P<0.05).The group treated with 99Tc-MDP showed the statistical difference in meliorating ankylosis

lessening the pain and swell

as well as reducing ESR and CRP(P<0.05～0.01).Conclusions:99Tc-MDP can efficiently and effectively improve the symptoms and laboratory indexes of rheumatoid arthritis in a safe way.

关键词

云克甲氨蝶呤来氟米特类风湿关节炎临床研究

Keywords

99Tc-MDPmethotrexateLeflunomiderheumatoid arthritisClinical research

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Department of Nephrology , College of Clinical Medicine , Chongqing Medical University

⁰

Influence of 99Tc-MDP combination therapy on clinical symptoms and laboratory indexes of rheumatoid arthritis

DOI：10.13406/j.cnki.cyxb.2010.11.018

摘要

Abstract

关键词

Keywords

references

Influence of ⁹⁹Tc-MDP combination therapy on clinical symptoms and laboratory indexes of rheumatoid arthritis