Distribution and drug resistance of pathogenic bacteria in patients receiving mechanical ventilation in ICU

SHU Chang; et al

doi:10.13406/j.cnki.cyxb.2010.11.012

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Distribution and drug resistance of pathogenic bacteria in patients receiving mechanical ventilation in ICU

更新时间：2024-01-17

- Distribution and drug resistance of pathogenic bacteria in patients receiving mechanical ventilation in ICU
- Journal of Chongqing Medical University Vol. 35, Issue 11, Pages: 1746-1750(2010)
- 作者机构：
  
  1. 重庆医科大学附属二院呼吸科
  2. 重庆市渝北区人民医院呼吸科
  3. 重庆医科大学附属二院微生物检验室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.11.012
  CLC： R446.5
- Published：2010，
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[1]舒畅,张黎,黄长武,王导新.ICU机械通气患者病原菌分布及耐药性分析[J].重庆医科大学学报,2010,35(11):1746-1750.

SHU Chang, et al. Distribution and drug resistance of pathogenic bacteria in patients receiving mechanical ventilation in ICU. [J]. Journal of Chongqing Medical University 35(11):1746-1750(2010)
[1]舒畅,张黎,黄长武,王导新.ICU机械通气患者病原菌分布及耐药性分析[J].重庆医科大学学报,2010,35(11):1746-1750. DOI： 10.13406/j.cnki.cyxb.2010.11.012.

SHU Chang, et al. Distribution and drug resistance of pathogenic bacteria in patients receiving mechanical ventilation in ICU. [J]. Journal of Chongqing Medical University 35(11):1746-1750(2010) DOI： 10.13406/j.cnki.cyxb.2010.11.012.

摘要

目的:了解我院重症监护病房（Intensive care unit

ICU）机械通气患者感染病原菌分布及耐药性变迁

指导临床合理用药。方法:回顾性调查分析2007年～2009年我院呼吸ICU和中心ICU有创机械通气患者下呼吸道分泌物及血液标本病原菌分布及药敏结果

数据分析采用WHONET5.4软件进行。结果:共分离病原菌2 850株

革兰阳性菌占15.2%

革兰阴性菌占70.1%

真菌占14.7%

2007年仅检出1株黄杆菌属菌株

2009年增加为76株。金葡菌及表皮葡萄球菌中苯唑西林耐药株分别占71.2%及96.6%

未发现耐万古霉素、利奈唑胺菌株;肺炎克雷伯菌和大肠杆菌ESBLs检出率平均占63.7%和62.1%

发现14株产KPC肺炎克雷伯菌株

鲍曼不动杆菌对亚胺培南的耐药率由2007年的0%上升到2009年的66.2%。结论:我院ICU有创机械通气患者感染病原菌以不发酵菌为主且呈现多重耐药

动态监测并定期公示病原菌构成及耐药情况

有助于临床合理选择抗生素。

Abstract

Objective:To investigate the tendency of pathogens distribution and drug resistance in patients receiving mechanical ventilation in ICU and to provide the reference for rational use of antimicrobial drugs.Methods:Pathogens distribution and resistant rate of patients receiving mechanical ventilation were analyzed by retrospective analysis.Data was analyzed by WHONET5.4 software.Results:A total of 2 850 pathogens strains were isolated

of which Gram-positive cocci

Gram-negative and fungi accounted for 15.2%

70.1% and 14.7% respectively

the strains of Flavobacterium increased from only one in 2007 to 76 in 2009.Methicillin resistant strains in S.aureus(MRSA) and S.epidermidis(MRSE) accounted for 71.2% and 96.6% respectively

no vancomycin or linezolid resistant strains were found; ESBLs positive rates of Klebsiella pneumoniae and Ecoli were 63.7% and 62.1% respectively

14 strains of KPC positive Klebsiella pneumoniae were found

the resistant rates of Acinetobacter baumannii to imipenem were 0% in 2007 and 66.2% in 2009.Conclusions :Non-fermentative gram-negative bacilli are the majority of the pathogens isolated from patients receiving mechanical ventilation

and some strains are multiresistant

surveillance of their prevalence and drug resistance may provide evidences for rational antibiotic choices.

关键词

重症监护病房机械通气病原菌耐药性

Keywords

Intensive care unitmechanical ventilationpathogensresistance

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