Effects of Safflor yellow on heart function and IL-1β mRNA expression of cardiac muscle after acute myocardial infarction in rats

LI Bo; et al

doi:10.13406/j.cnki.cyxb.2010.11.006

您当前的位置：

首页 >

文章列表页 >

Effects of Safflor yellow on heart function and IL-1β mRNA expression of cardiac muscle after acute myocardial infarction in rats

更新时间：2024-01-17

- Effects of Safflor yellow on heart function and IL-1β mRNA expression of cardiac muscle after acute myocardial infarction in rats
- Journal of Chongqing Medical University Vol. 35, Issue 11, Pages: 1668-1671(2010)
- 作者机构：
  
  重庆医科大学附属第二医院心内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.11.006
  CLC： R285.5
- Published：2010，
扫描看全文
[1]李波,邓昌明,吴艳,周大燕,刘地川,黄晶.PAF拮抗剂红花黄色素对急性心肌梗死大鼠心功能及心肌IL-1β mRNA表达的影响[J].重庆医科大学学报,2010,35(11):1668-1671.

LI Bo, et al. Effects of Safflor yellow on heart function and IL-1β mRNA expression of cardiac muscle after acute myocardial infarction in rats. [J]. Journal of Chongqing Medical University 35(11):1668-1671(2010)
[1]李波,邓昌明,吴艳,周大燕,刘地川,黄晶.PAF拮抗剂红花黄色素对急性心肌梗死大鼠心功能及心肌IL-1β mRNA表达的影响[J].重庆医科大学学报,2010,35(11):1668-1671. DOI： 10.13406/j.cnki.cyxb.2010.11.006.

LI Bo, et al. Effects of Safflor yellow on heart function and IL-1β mRNA expression of cardiac muscle after acute myocardial infarction in rats. [J]. Journal of Chongqing Medical University 35(11):1668-1671(2010) DOI： 10.13406/j.cnki.cyxb.2010.11.006.

摘要

目的:探讨血小板活化因子（Platelet activating factor

PAF）拮抗剂红花黄色素对急性心肌梗死大鼠心功能及心肌白介素细胞-1β（Interleukin-1β

IL-1β）表达的影响。方法:将54只SD大鼠随机分成假手术组、心梗组和红花黄色素治疗组

采用结扎左冠状动脉前降支方法建立急性心肌梗死动物模型

术后24 h治疗组给予腹腔内注射红花黄色素40 mg（/kg.d）

心梗组和假手术组给予相同体积的生理盐水腹腔内注射。28 d后用Vivid 7型多普勒超声仪检测各组大鼠心功能

计算左室重量指数

用RT-PCR法检测IL-1βmRNA水平表达。结果:与假手术组相比

心梗组和治疗组心功能明显降低（P<0.05）;与心梗组比较

治疗组心功能明显好转（P<0.05）。与假手术组相比

心梗组和治疗组左室重量指数、IL-1βmRNA水平的表达明显增加（P<0.05）;和心梗组比较

治疗组左室重量指数及IL-1βmRNA表达减少（P<0.05）。结论:PAF拮抗剂红花黄色素可通过改善急性心肌梗死大鼠心室重构

调节炎性细胞因子IL-1β的表达

从而改善急性心肌梗死大鼠心功能。

Abstract

Objective:To investigate the effects of platelet activating factor(PAF) antagonist Safflor yellow on the heart function and IL-1β mRNA expression of cardiac muscle in rats after acute myocardial infarction.Methods:54 SD rats were randomly divided into sham group

MI group and treatment group;acute myocardial infarction animal models were established by ligation of LAD;rats of treatment group were intervened by injecting intraperitoneally with 40 mg/(kg·d) safflor yellow after 24h;the MI group and sham group were injected with equal volume of saline.The heart functions were detected by Vivid 7-type Doppler ultrasound after 28 days;the left ventricular weight index were calculated and the IL-1β mRNA expression of cardiac muscle was detected by RT-PCR.Results:Compared with sham group

the heart function of MI group and treatment group were significantly depressed (P<0.05);and that of treatment group was better than that of MI group(P<0.05).Compared with sham group

the left ventricular weight index and IL-1β mRNA expression of cardiac muscle in MI group and treatment group were increased significantly(P<0.05);and the left ventricular weight index in treatment group was less than that in MI group;the IL-1β mRNA in treatment group was expressed less than that in MI group(P<0.05).Conclusions: Platelet activating factor(PAF) antagonist Safflor yellow can improve the heart function in rats after acute myocardial infarction by improving left ventricular remodeling and regulating IL-1β expression.

关键词

心肌梗死血小板活化因子（PAF）拮抗剂心功能IL-1β大鼠

Keywords

myocardial infarctionPlatelet activating factor(PAF) antagonistHeart functionIL-1 βrats

references

Views

161

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

AT1-AA expression of patients with essential hypertension complicated with myocardial infarction and effect of AT1-AA on the coronary artery in rats

Protection and mechanism of zinc sulfate combined with aspirin for acute myocardial infarction

THE EFFECT OF INFARCT EXPANSION ON LEFT VENTRICULAR FUNCTION IN RATS

THE ALTERATIONS OF RENAL AND HEMODYNAMIC EFFECTS OF NATRIURETIC FACTOR IN ATRIA OF THE RATS WITH ACUTE HEART FAILURE

THE TRANSFERABLE AND IMMUNOLOGICAL STUDIES ON SHOCK TOXIN

Related Author

Zhang Yuan

Zhong Xiaoming

Li Yanming

Fu Hairong

Department of Pathophysiology: Du Xiaojun

Department of Pathophysiology Du Xiaojun

Gong Xuling

et al

Related Institution

Department of Cardiovascular Medicine,Huaihe River Hospital of Henan University

Chongqing Three Gorges Medical College

重庆医学院病理生理教研室

重庆医科大学病理生理学教研室

Department of Pharmacology

⁰