Correlative analysis between eIF4E and VEGF expression and angiogenesis and metastasis of human esophageal carcinoma

MA Min-jie; et al

doi:10.13406/j.cnki.cyxb.2010.11.001

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Correlative analysis between eIF4E and VEGF expression and angiogenesis and metastasis of human esophageal carcinoma

更新时间：2024-01-17

- Correlative analysis between eIF4E and VEGF expression and angiogenesis and metastasis of human esophageal carcinoma
- Journal of Chongqing Medical University Vol. 35, Issue 11, Pages: 1634-1638(2010)
- 作者机构：
  
  兰州大学第一医院胸心外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.11.001
  CLC： Q756
- Published：2010，
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[1]马敏杰,韩彪,刘健,魏宁,张瑜,徐上清.真核细胞翻译起始因子4E、血管内皮生长因子与食管癌血管生成及转移的关系[J].重庆医科大学学报,2010,35(11):1634-1638.

MA Min-jie, et al. Correlative analysis between eIF4E and VEGF expression and angiogenesis and metastasis of human esophageal carcinoma. [J]. Journal of Chongqing Medical University 35(11):1634-1638(2010)
[1]马敏杰,韩彪,刘健,魏宁,张瑜,徐上清.真核细胞翻译起始因子4E、血管内皮生长因子与食管癌血管生成及转移的关系[J].重庆医科大学学报,2010,35(11):1634-1638. DOI： 10.13406/j.cnki.cyxb.2010.11.001.

MA Min-jie, et al. Correlative analysis between eIF4E and VEGF expression and angiogenesis and metastasis of human esophageal carcinoma. [J]. Journal of Chongqing Medical University 35(11):1634-1638(2010) DOI： 10.13406/j.cnki.cyxb.2010.11.001.

摘要

目的:探讨真核细胞翻译起始因子4E（Eukaryotic initiation factor 4E

eIF4E）、血管内皮生长因子（Vascular endothelial growth factor

VEGF）在食管癌中的表达及其意义。方法:应用免疫组化S-P法检测131例食管癌组织及20例癌旁组织中eIF4E

VEGF及微血管密度（Micro vessel density

MVD）的表达。结果:eIF4E、VEGF在食管癌中的表达高于正常食管组织（P=0.000、P=0.002

P<0.05）

且eIF4E和VEGF的表达与食管癌的浸润深度（P=0.001、P=0.004

P<0.05）、淋巴结转移情况（P=0.01、P=0.003

P<0.05）及临床分期显著相关（P=0.026、P=0.025

P<0.05）。结论:eIF4E、VEGF协同表达对血管生成、食管癌的浸润、转移起到关键性的作用

可能为食管癌治疗中的一个新靶点。

Abstract

Objective:To investigate the expression of eIF4E and vascular endothelial growth factor (VEGF) on neoangiogenesis and metastasis of human esophageal carcinoma.Methods:Immunohistochemistry was used to study the expression of eIF4E

VEGF and microvessel density(MVD) in 131 cases of esophageal carcinoma tissues.VEGF and eIF4E were detected also in 20 cases of adjacent normal esophageal tissues.CD34 was used to explore the microvessel density(MVD) as marker of endothelial cell.Results:eIF4E and VEGF showed a higher expression in esophageal carcinoma tissues than normal esophageal tissues.The expression of eIF4E and VEGF were significantly related to clinico-pathological features(depth of invasion

lymph-node metastasis and TNM stage) and MVD.Conclusion:the co-expression of eIF4E and VEGF plays a key role in angiogenesis

invasion and metastasis of esophageal carcinoma.eIF4E and VEGF may serve as a new target for the treatment of esophageal cancer.

关键词

食管肿瘤血管内皮生长因子血管生成肿瘤转移

Keywords

Esophageal carcinomavascular endothelial growth factorangiogenesisMetastasis

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