Expression of E-cadherin in pancreatic carcinoma and its association with angiogenesis

FEI Yang; et al

doi:10.13406/j.cnki.cyxb.2010.10.041

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Expression of E-cadherin in pancreatic carcinoma and its association with angiogenesis

更新时间：2024-01-17

- Expression of E-cadherin in pancreatic carcinoma and its association with angiogenesis
- Journal of Chongqing Medical University Vol. 35, Issue 10, Pages: 1502-1505(2010)
- 作者机构：
  
  1. 解放军第八一医院普通外科
  2. 东南大学附属中大医院普通外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.10.041
  CLC： R735.9
- Published：2010，
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[1]费阳,刘绪舜,王峰,王伟,刘胜利.E-cadherin在胰腺癌中的表达及与血管生成的关系[J].重庆医科大学学报,2010,35(10):1502-1505.

FEI Yang, et al. Expression of E-cadherin in pancreatic carcinoma and its association with angiogenesis. [J]. Journal of Chongqing Medical University 35(10):1502-1505(2010)
[1]费阳,刘绪舜,王峰,王伟,刘胜利.E-cadherin在胰腺癌中的表达及与血管生成的关系[J].重庆医科大学学报,2010,35(10):1502-1505. DOI： 10.13406/j.cnki.cyxb.2010.10.041.

FEI Yang, et al. Expression of E-cadherin in pancreatic carcinoma and its association with angiogenesis. [J]. Journal of Chongqing Medical University 35(10):1502-1505(2010) DOI： 10.13406/j.cnki.cyxb.2010.10.041.

摘要

目的:探讨胰腺癌组织中E-钙粘素（E-cadherin）的表达与胰腺癌临床病理特征及预后的关系

及E-cadherin在胰腺癌血管生成中的作用。方法:采用免疫组化Power Vision法对49例胰腺癌组织及癌旁正常胰腺组织的E-cadherin、血管内皮生长因子（Vascular endothelial growth factor

VEGF）和CD34抗体的表达情况进行检测。结果:胰腺癌组织中E-cadherin阳性表达阳性率为73.5%

癌旁正常胰腺组织阳性率仅为16.3%

两者比较差异有统计学意义（P<0.05）。E-cadherin蛋白和VEGF蛋白表达呈正相关（P<0.05）;E-cadherin阳性组的微血管密度（Microvessel density

MVD）值明显高于阴性低表达组（P<0.05）。E-cadherin的表达与胰腺癌组织的分化程度、浸润程度、血管侵袭、淋巴结转移及pTNM分期呈明显相关（P<0.05）。E-cadherin阳性表达组患者的中位生存时间（18.00±3.65）月低于阴性表达组（30.00±8.01）月

阳性表达组的预后显著差于阴性表达组

差异有统计学意义（P<0.05）。结论:E-cadherin的异常表达可作为评价胰腺癌预后的辅助指标。E-cadherin可能激活VEGF通道

从而诱导胰腺癌血管的生成。

Abstract

Objective:Toinvestigate the association ofE-cadherin expression with the clinicopathologic features

prognosis and angiogenesis in pancreatic carcinoma. Methods:Immunohistochemistry(Power Vision method)were performed to investigate the expression of E-cadherin protein

VEGF protein and CD34 in 49 patients with pancreatic carcinoma. Results:Reduced or loss of membranous expression and cytoplasmic localization of E-cadherin protein were found in pancreatic cancer tissues (36/49

73.5%)by using immunohistochemistry. Moreover there was an positive relationship among E-cadherin protein

VEGF protein and microvessel density expression (P<0.05)in pancreatic cancer tissues. Reduced expression of E-cadherin occurred more frequently in poor differentiation (χ 2 = 8.279

P<0.05)

positive lymph metastasis(χ 2 =4.045

P<0.05)

positive vascular invasion(χ 2 = 4.738

P<0.05)

deeper invasion(χ 2 = 8.653

P<0.05)and advanced stage (χ 2 = 11.006

P <0.05).Additionally

reduced expression of E-cadherin protein in tumor correlated with a worse prognosis and normal expression with a better survival rate(P=0.023).Conclusion:The altered expression of E-cadherin can be regarded as an assistant marker in evaluating the prognosis of pancreatic carcinoma. E-cadherin may activate VEGF-channels

and induce the angiogenesis of pancreatic carcinoma.

关键词

胰腺癌E-cadherin血管生成预后

Keywords

Pancreatic carcinomaE-cadherinangiogenesisprognosis

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