Efficacy of glargine on type2 diabetic patients whose treatment fail with premixed insulin

LONG Jian; et al

doi:10.13406/j.cnki.cyxb.2010.10.018

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Efficacy of glargine on type2 diabetic patients whose treatment fail with premixed insulin

更新时间：2024-01-17

- Efficacy of glargine on type2 diabetic patients whose treatment fail with premixed insulin
- Journal of Chongqing Medical University Vol. 35, Issue 10, Pages: 1560-1562(2010)
- 作者机构：
  
  重庆医科大学附属第一医院内分泌科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.10.018
  CLC： R587.1
- Published：2010，
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[1]龙健,龚莉玲,李启富.预混胰岛素转换为甘精胰岛素治疗的疗效分析[J].重庆医科大学学报,2010,35(10):1560-1562.

LONG Jian, et al. Efficacy of glargine on type2 diabetic patients whose treatment fail with premixed insulin. [J]. Journal of Chongqing Medical University 35(10):1560-1562(2010)
[1]龙健,龚莉玲,李启富.预混胰岛素转换为甘精胰岛素治疗的疗效分析[J].重庆医科大学学报,2010,35(10):1560-1562. DOI： 10.13406/j.cnki.cyxb.2010.10.018.

LONG Jian, et al. Efficacy of glargine on type2 diabetic patients whose treatment fail with premixed insulin. [J]. Journal of Chongqing Medical University 35(10):1560-1562(2010) DOI： 10.13406/j.cnki.cyxb.2010.10.018.

摘要

目的:明确预混胰岛素联合口服药治疗失败的2型糖尿病患者转换为甘精胰岛素联合口服药治疗后能否提高血糖达标率。方法:将预混胰岛素联合口服药治疗但血糖控制不达标的2型糖尿病患者转换为甘精胰岛素联合口服药治疗

分析转换前后血糖的达标情况。结果:转换为甘精胰岛素联合口服药治疗后

空腹血糖达标率为80.77%

餐后2 h血糖达标率为72%

糖化血红蛋白小于7%的达标率为15.38%

糖化血红蛋白<7.5%的达标为46.15%的患者。糖化血红蛋白较转换前平均下降0.6%。结论:对于2型糖尿病患者

如预混胰岛素联合口服药治疗不达标者可以转换为甘精胰岛素联合口服药治疗

转换后可进一步促使血糖下降

增加血糖达标比率

且转换后胰岛素使用剂量较前明显减少。

Abstract

Objective:To identify the glucose control rates oftreatment with glargine combined with oral drugs in type 2 diabetes mellitus patients whose treatment were failed with premixed insulin combined with oral drugs. Methods:Type 2 diabetes mellitus patients whose treatment were failed with premixed insulin combined with oral drugs were switched to treatment with glargine combined with oral drugs; control rates were analyzed after switching. Results:After switching

80.77% of the patients achieved fast glucose control; 72% of the patients achieved postprandial glucose control ;15.38% of the patients achieved an HbA1c level of 7%

and 46.15% achieved 7.5% .The mean reduction of HbA1c was 0.6% . Total mean insulin use was decreased. Conclusion:Type 2 diabetes mellitus patients whose treatment were failed with premixed insulin combined with oral drugs can be switched to treatment with glargine combined with oral drugs. After the switch

serum glucose level in patients’blood will decrease; glucose control rates will increase

and total mean insulin use will decrease.

关键词

2型糖尿病预混胰岛素甘精胰岛素达标率

Keywords

type 2 diabetes mellitusPremixed insulinGlargineControl rate

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