The distribution of HPV infections in women seeking for examination in Chongqing yongchuan area

ZHANG Xiao-Jing; et al

doi:10.13406/j.cnki.cyxb.2010.09.039

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The distribution of HPV infections in women seeking for examination in Chongqing yongchuan area

更新时间：2024-01-17

- The distribution of HPV infections in women seeking for examination in Chongqing yongchuan area
- Journal of Chongqing Medical University Vol. 35, Issue 9, Pages: 1407-1410(2010)
- 作者机构：
  
  1. 重庆医科大学附属永川医院妇产科
  2. 重庆医科大学附属第一医院妇产科
  3. 重庆医科大学附属永川医院检验科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.09.039
  CLC： R737.33
- Published：2010，
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[1]张晓静,袁瑞,代红莹.重庆永川地区妇科门诊人乳头瘤病毒亚型分布的研究[J].重庆医科大学学报,2010,35(09):1407-1410.

ZHANG Xiao-Jing, et al. The distribution of HPV infections in women seeking for examination in Chongqing yongchuan area. [J]. Journal of Chongqing Medical University 35(9):1407-1410(2010)
[1]张晓静,袁瑞,代红莹.重庆永川地区妇科门诊人乳头瘤病毒亚型分布的研究[J].重庆医科大学学报,2010,35(09):1407-1410. DOI： 10.13406/j.cnki.cyxb.2010.09.039.

ZHANG Xiao-Jing, et al. The distribution of HPV infections in women seeking for examination in Chongqing yongchuan area. [J]. Journal of Chongqing Medical University 35(9):1407-1410(2010) DOI： 10.13406/j.cnki.cyxb.2010.09.039.

摘要

目的:了解23种人乳头瘤病毒（Human papillo maviruses

HPV）型别在永川地区人群中的感染情况及分布特点

为本地区人乳头瘤病毒感染诊断及其相关疾病的防治提供重要依据。方法:应用基于反向膜杂交的基因芯片技术对665例临床送检标本进行分型检测

所得数据用SPSS等软件进行统计分析。结果:HPV总感染率为37.65%

23种基因型检出20种

其中单一型别感染率为27.25%

两型混合感染率为7.22%

3型（包括3型）以上混合感染率为3.18%。HPV亚型分布情况为:HPV16型9.92%、HPV6型5.74%、HPV11型4.36%、HPV33型1.32%、HPV58型1.05%、HPV43型1.02%、HPV18型0.75%

其余型别3.29%;高危型HPV在≤20、21～30、31～40、>40年龄组的感染率依次为14.1%、15.2%、17.2%、17.3%（χ2=3.0

P>0.05）

组间比较差异无显著性;低危型HPV在各年龄组的感染率依次为20.3%、11.7%、10.1%、10.1%（χ2=23.28

P<0.01）

组间比较差异具有显著性。结论:本地区人群HPV感染率较高

且以单一亚型感染为主

其中HPV16为高危型HPV感染主要的型别

低危型HPV感染以HPV6和HPV11为主;HPV各型别的感染率与年龄有一定的关系

该结果为防治宫颈癌、尖锐湿疣等其它HPV相关疾病提供了理论依据。

Abstract

Objective:To comprehend the status of infection as well as distribution of types of Human papillomaviruses(HPV) and provide evidence for diagnosis and prevention.Methods:665 samples were detected and genotyped with the technology of gene chips.The data was analyzed with the statistical software SPSS13.0.Results:①37.65% of those samples were detected positive for HPV infection and 20 HPV genotypes were detected successfully.Among them

27.25% were infected by single HPV genotype

7.22% were infected by two genotypes and 3.18% were infected by three genotypes.In the single infection of HPV

the percentages of 16

18 were 9.92%

5.74%

4.36%

1.32%

1.05%

1.02%

0.75% respectively

and the rate of others of other genotypes were 3.29%.②The rates of different age group of high risk HPV were 14.1%(≤20)

15.2%(21～30)

17.2%(31～40)

17.3%(>40)(χ2=3.0

P>0.05).The rates of different age group of low risk HPV were 20.3%(≤20)

11.7%(21～30)

10.1%(31～40)

10.1%(>40)(χ2=23.28

P<0.01)

a statistically significant difference between the groups.Conclusion:①In the area of Sichuan

HPV infection situation was comparatively severe and most were single infection.Among the high risk HPV infections

HPV16 prevalence was highest

and among the low risk HPV infections

types 6 and 11 were the most prevalent.②Age had certain something to do with HPV infection.③The present study palyed an important role in preventing and treating the diseases caused by HPV

such as cervical cancer

condylomata acuminate.

关键词

人乳头瘤病毒型别分布宫颈癌尖锐湿疣

Keywords

Human papillomavirusesTypes distributioncervical cancerCondylomata acuminate

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