Expression of the Pin1 in the hepatitis,cirrhosis and hepatocelluar carcinoma tissues and its relationship with hepatitis B virus by tissue microarray

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Expression of the Pin1 in the hepatitis,cirrhosis and hepatocelluar carcinoma tissues and its relationship with hepatitis B virus by tissue microarray

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- Expression of the Pin1 in the hepatitis,cirrhosis and hepatocelluar carcinoma tissues and its relationship with hepatitis B virus by tissue microarray
- Journal of Chongqing Medical University Vol. 35, Issue 9, Pages: 1377-1380(2010)
- 作者机构：
  
  1. 重庆医科大学附属第二医院感染科
  2. 美国得克萨斯大学MD安德森癌症中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.09.036
  CLC： R735.7
- Published：2010，
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[1]许晓梅,胡怀东,廖勇,张大志.应用组织芯片检测Pin1在肝炎、肝硬化、肝细胞性肝癌组织中的表达[J].重庆医科大学学报,2010,35(09):1377-1380.

XU Xiao-mei, et al. Expression of the Pin1 in the hepatitis,cirrhosis and hepatocelluar carcinoma tissues and its relationship with hepatitis B virus by tissue microarray. [J]. Journal of Chongqing Medical University 35(9):1377-1380(2010)
[1]许晓梅,胡怀东,廖勇,张大志.应用组织芯片检测Pin1在肝炎、肝硬化、肝细胞性肝癌组织中的表达[J].重庆医科大学学报,2010,35(09):1377-1380. DOI： 10.13406/j.cnki.cyxb.2010.09.036.

XU Xiao-mei, et al. Expression of the Pin1 in the hepatitis,cirrhosis and hepatocelluar carcinoma tissues and its relationship with hepatitis B virus by tissue microarray. [J]. Journal of Chongqing Medical University 35(9):1377-1380(2010) DOI： 10.13406/j.cnki.cyxb.2010.09.036.

摘要

目的:利用组织芯片技术检测肽基脯氨酰顺反异构酶（Peptidyl-proplyl isomerase1

pin1）在正常、肝炎、肝硬化及肝癌组织中的表达

了解pin1在肝细胞性肝癌发生、发展不同阶段的表达情况及与临床病理参数的关系。方法:用免疫组织化学染色法在组织芯片上同时检测10例HBsAg阳性病毒性肝炎、40例肝硬化、19例肝细胞性肝癌及34例正常肝组织中pin1的表达情况

并分析pin1在不同肝脏疾病组织中的表达差异。结果:pin1在HBsAg阳性病毒性肝炎、肝硬化、肝细胞性肝癌及正常肝组织中的阳性表达率分别为80%（8/10）、82.5%（33/40）、100%（19/19）、55.8%（19/34）

肝细胞性肝癌组织中的阳性表达率明显高于HBsAg阳性病毒性肝炎、肝硬化及正常肝组织

同时肝癌中pin1的表达强度也明显高于HBsAg阳性病毒性肝炎、肝硬化和正常肝组织（P<0.001）

而在HBsAg阳性病毒性肝炎、肝硬化和正常肝组织中pin1阳性表达率及表达强度均无差异无统计学意义（P>0.001）;肝细胞性肝癌组织中pin1的表达与病理分级、有无淋巴结转移及临床分期无相关性（P>0.05）。结论:pin1参与了HBsAg阳性病毒性肝炎

肝硬化到肝细胞性肝癌的疾病进展过程

在肝细胞性肝癌的发生和发展中发挥了一定作用。

Abstract

Objective:By using tissue microarray technique to detect the expression of peptidyl-proplyl isomerase 1(pin1) in human hepatitis B

cirrhosis

hepatocelluar carcinoma(HCC) and normal liver tissue

discussing its role in different stage of oncogenesis of HCC

and its relationship with clinicopathological parameter.Methods:Immunohistochemistry was used to detect the expression of pin1 in 10 cases of hepatitis B

40 cases of cirrhosis

19 cases of HCC and 34 cases of normal liver tissue.Results:The positive expression rate and intensity of pin1 was stronger in the HCC than that in the hepatitis B

cirrhosis and normal liver tissue(P<0.001)

but there was no significant difference in the latter three tissues(P>0.001).The expression of pin1 was not correlated with clinicopathological parameter(P>0.05).Conclusion:pin1 plays a pivotal role in different stages of HCC.

关键词

PIN1HBsAg阳性病毒性肝炎肝硬化肝细胞性肝癌组织芯片

Keywords

PIN1Hepatitis BcirrhosisHepatocelluar carcinomatissue microarray

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