Significance of golgi α-mannosidase Ⅱ,E-Cadherin,Galectin-3 expression and their correlation in human gastric carcinoma

YANG Ya-ying; et al

doi:10.13406/j.cnki.cyxb.2010.09.031

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Significance of golgi α-mannosidase Ⅱ,E-Cadherin,Galectin-3 expression and their correlation in human gastric carcinoma

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- Significance of golgi α-mannosidase Ⅱ,E-Cadherin,Galectin-3 expression and their correlation in human gastric carcinoma
- Journal of Chongqing Medical University Vol. 35, Issue 9, Pages: 1313-1317(2010)
- 作者机构：
  
  重庆医科大学基础学院病理学教研室、分子医学与肿瘤研究中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.09.031
  CLC： R735.2
- Published：2010，
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[1]杨雅莹,李艳青,易永芬,何婷婷,肖钟.高尔基体α-甘露糖苷酶Ⅱ在胃癌中的表达及其与E-cadherin、Galectin-3的关系[J].重庆医科大学学报,2010,35(09):1313-1317.

YANG Ya-ying, et al. Significance of golgi α-mannosidase Ⅱ,E-Cadherin,Galectin-3 expression and their correlation in human gastric carcinoma. [J]. Journal of Chongqing Medical University 35(9):1313-1317(2010)
[1]杨雅莹,李艳青,易永芬,何婷婷,肖钟.高尔基体α-甘露糖苷酶Ⅱ在胃癌中的表达及其与E-cadherin、Galectin-3的关系[J].重庆医科大学学报,2010,35(09):1313-1317. DOI： 10.13406/j.cnki.cyxb.2010.09.031.

YANG Ya-ying, et al. Significance of golgi α-mannosidase Ⅱ,E-Cadherin,Galectin-3 expression and their correlation in human gastric carcinoma. [J]. Journal of Chongqing Medical University 35(9):1313-1317(2010) DOI： 10.13406/j.cnki.cyxb.2010.09.031.

摘要

目的:探讨胃癌高尔基体α-甘露糖苷酶Ⅱ（Golgiα-mannosidaseⅡ

GMⅡ）、E-cadherin、Galectin-3的表达及其与胃癌发生发展的关系。方法:应用免疫组化SP法检测65例胃癌

20例正常胃黏膜组织中GMⅡ、E-cadherin、Galectin-3的表达情况。结果:65例胃癌中GMⅡ、E-cadherin、Galectin-3的阳性表达率分别为85%（55/65）、40%（26/65）、74%（48/65）。20例胃正常切缘中GMⅡ、E-cadherin、Galectin-3的阳性表达率分别为50%（10/20）、100%（20/20）、40%（8/20）。GMⅡ、Galectin-3在浸润程度深及有淋巴结转移的胃癌组织中表达明显高于浸润程度浅及无淋巴结转移的胃癌组织（P<0.05）。而E-cadherin则在分化程度低

浸润程度深及有淋巴结转移的胃癌组织中表达明显低于分化程度高

浸润程度浅及无淋巴结转移的胃癌组织（P<0.05）。统计学分析GMⅡ与E-cadherin之间呈负相关（P<0.05）

与Galectin-3无相关性（P>0.05）。结论:GMⅡ、Galectin-3在胃癌中高表达

且与癌组织的浸润和转移明显相关。同时GMⅡ与E-cadherin呈负相关

提示GMⅡ可能通过下调E-cadherin的表达来促进胃癌的发展。

Abstract

Objective:To investigate the expression of GMⅡ

E-cadherin

and Galectin-3

and their roles in tumorigenesis and progression of gastric cancer.Methods:Immunohistochemistry SP method was used to determine expression of GMⅡ

E-cadherin

and Galectin-3 in gastric carcinoma(n=65) and normal gastric mucosa(n=20).Results:The positive rates of GMⅡ

E-cadherin

and Galectin-3 were respectively 85%(55/65)

40%(26/65)

and 74%(48/65) in gastric cancer ;their were respectively 50%(10/20)

100%(20/20)

and 40%(8/20) in normal gastric mucosa.The expressions of GMⅡ

E-cadherin

and Galectin-3 were significantly different between tissues from carcinoma and those from normal mucosa(P<0.05).The expressions of GMⅡand E-cadherin were significantly related to poor differentiation

deep invasion and lymph node metastasis.GMⅡ expression had a negative correlation with E-cadherin(P<0.05)

but no correlation with galectin-3(P>0.05).The expression of galectin-3 was markedly related to the depth of invasion

lymph node metastasis

but not to tumor differentiation.Conclusion:Up-regulated expression of GMⅡ

Galectin-3 play important roles in the invasion and metastasis of gastric carcinoma.There is a significant negative correlation between GMⅡ and E-cadherin

suggesting that GMⅡ may promote the development of gastric carcinoma through down-regulating expression of E-cadherin.

关键词

胃癌高尔基体α-甘露糖苷酶ⅡE-cadherinGalectin-3胃癌免疫组化

Keywords

GMⅡE-cadherinGalectin-3gastric carcinomaimmunohistochemistry

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