Expression of cyclinD1,P16 and PCNA in ectopic and eutopic endometrium tissues of patients with endometrtosis and their clinical significance

LONG Xing-tao; et al

doi:10.13406/j.cnki.cyxb.2010.09.022

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Expression of cyclinD1,P16 and PCNA in ectopic and eutopic endometrium tissues of patients with endometrtosis and their clinical significance

更新时间：2024-01-17

- Expression of cyclinD1,P16 and PCNA in ectopic and eutopic endometrium tissues of patients with endometrtosis and their clinical significance
- Journal of Chongqing Medical University Vol. 35, Issue 9, Pages: 1309-1312(2010)
- 作者机构：
  
  重庆医科大学附属第一医院妇产科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.09.022
  CLC： R711.71
- Published：2010，
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[1]龙行涛,唐良萏,周敏,张婧.细胞周期蛋白D1、P16与PCNA在子宫内膜异位症在位和异位内膜组织中的表达研究[J].重庆医科大学学报,2010,35(09):1309-1312.

LONG Xing-tao, et al. Expression of cyclinD1,P16 and PCNA in ectopic and eutopic endometrium tissues of patients with endometrtosis and their clinical significance. [J]. Journal of Chongqing Medical University 35(9):1309-1312(2010)
[1]龙行涛,唐良萏,周敏,张婧.细胞周期蛋白D1、P16与PCNA在子宫内膜异位症在位和异位内膜组织中的表达研究[J].重庆医科大学学报,2010,35(09):1309-1312. DOI： 10.13406/j.cnki.cyxb.2010.09.022.

LONG Xing-tao, et al. Expression of cyclinD1,P16 and PCNA in ectopic and eutopic endometrium tissues of patients with endometrtosis and their clinical significance. [J]. Journal of Chongqing Medical University 35(9):1309-1312(2010) DOI： 10.13406/j.cnki.cyxb.2010.09.022.

摘要

目的:探讨细胞周期蛋白D1（CyclinD1）、P16与增殖细胞核抗原（Proliferating cell nuclear antigen

PCNA）在子宫内膜异位症发生发展中作用。方法:应用SABC免疫组化技术检测子宫内膜异位症患者（观察组）在位内膜（25例）及异位子宫内膜（28例）和其它良性病变妇女子宫内膜组织（对照组

35例）中cyclinD1、P16及PCNA蛋白表达水平。结果:PCNA蛋白在异位内膜阳性表达均明显高于在位内膜及对照组（P<0.05）;CyclinD1蛋白在异位内膜中阳性表达明显高于在位内膜和对照组（P<0.05）;P16蛋白在对照组中阳性表达均明显高于在位内膜及异位内膜（P<0.05）。CyclinD1和P21蛋白在异位内膜中表达呈显著负相关性（kappa系数为-0.521

P<0.01）。三者在异位内膜增生期与分泌期表达无显著差异性（P>0.05）。结论:cyclinD1、P21及PCNA蛋白异常表达在子宫内膜异位症异位内膜增殖中起重要作用。

Abstract

Objective:To investigate the possible roles of CyclinD1

P16 and PCNA play in the pathogenesis and development of endometriosis.Methods:Twenty-five specimens of eutopic endometrium and Twenty-eight specimens of ectopic endometrium tissues were obtained from 28 patients with endometriosis(observation group).Thirty-five specimens of endometrium were also obtained from women with other benign diseases(control group).CyclinD1

P16 and PCNA was detected by immunohistochemistry.Results:The positive expression of PCNA protein in ectopic endometrium was significantly higher than that in the eutopic endometrium and control group(P<0.05).The positive expression of CyclinD1 protein in ectopic endometrium was significantly higher than that in the eutopic endometrium and control group(P<0.05).The positive expression of P16 in control group was significantly higher than that in the eutopic endometrium and ectopic endometrium(P<0.05).It showed that in the ectopic endometrium the positive expression of CyclinD1 and P16 were negatively spearman correlation(kappa coefficient =-0.521

P<0.01).The positive expression of CyclinD1

P16 and PCNA protein in proliferative phase compared with the secretory phase of the eutopic endometrium

there was no significant difference(P>0.05).Conclusion:The abnormality expression of CyclinD1、P16 and PCNA in the ectopic endometrium may be involved in the proliferation of endometrium in endometriosis.

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细胞周期蛋白D1子宫内膜异位症子宫内膜

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