Balofloxacin and levofloxacin in the treatment of 215 cases of bacterial infections in urinary system lower respiratory tract

XIN Xiao-juan; et al

doi:10.13406/j.cnki.cyxb.2010.08.022

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Balofloxacin and levofloxacin in the treatment of 215 cases of bacterial infections in urinary system lower respiratory tract

更新时间：2024-01-17

- Balofloxacin and levofloxacin in the treatment of 215 cases of bacterial infections in urinary system lower respiratory tract
- Journal of Chongqing Medical University Vol. 35, Issue 8, Pages: 1248-1251(2010)
- 作者机构：
  
  1. 重庆医科大学附属第一医院感染科
  2. 北京朝阳医院泌尿科
  3. 西安交通大学第二附属医院肾内科
  4. 浙江大学医学院附属第二医院肾内科
  5. 四川大学华西医院感染科
  6. 重庆医科大学附属第二医院肾内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.08.022
  CLC： R691.3
- Published：2010，
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[1]辛小娟,袁喆,黄文祥,李崇智,杨勇,桂保松,梁华,冯萍,钟玲.巴洛沙星治疗细菌性尿路感染的随机对照临床试验[J].重庆医科大学学报,2010,35(08):1248-1251.

XIN Xiao-juan, et al. Balofloxacin and levofloxacin in the treatment of 215 cases of bacterial infections in urinary system lower respiratory tract. [J]. Journal of Chongqing Medical University 35(8):1248-1251(2010)
[1]辛小娟,袁喆,黄文祥,李崇智,杨勇,桂保松,梁华,冯萍,钟玲.巴洛沙星治疗细菌性尿路感染的随机对照临床试验[J].重庆医科大学学报,2010,35(08):1248-1251. DOI： 10.13406/j.cnki.cyxb.2010.08.022.

XIN Xiao-juan, et al. Balofloxacin and levofloxacin in the treatment of 215 cases of bacterial infections in urinary system lower respiratory tract. [J]. Journal of Chongqing Medical University 35(8):1248-1251(2010) DOI： 10.13406/j.cnki.cyxb.2010.08.022.

摘要

目的:评价巴洛沙星治疗泌尿道细菌性感染的有效性及安全性。方法:采用多中心随机双盲对照临床试验设计。选用215例病人

随机分配到试验组（105例

予巴洛沙星）或对照组（110例

予左氧氟沙星）。给药方案均为0.1g

bid

疗程为5～14d。结果:试验组与对照组的痊愈率与有效率分别为77.1%、81.8%与96.2%、97.3%

细菌阳性率分别为78%与77.3%

细菌清除率分别为95.1%与94.1%

不良反应发生率分别为8.2%与8.9%

差异均无统计学意义（P>0.05）。结论:巴洛沙星是治疗下泌尿道细菌感染的非常有效和安全的药物

与左氧氟沙星相当。

Abstract

Objective:To evaluate the clinical efficacy and safety of balofloxacin in the treatment of bacterial infections in urinary system. Methods:A total of Two-hundred and twenty-nine patients with respiratory infections were enrolled in this multicenter

randomized controlled clinical study.One-hundred and five patients as trial group received balofloxacin and One-hundred and ten patients as control group received levofloxacin.Both groups were given drug 0.1g twice daily

period for 5 to 14 days.Results:The cure and effective rates were 77.1%and 96.2%

respectively in balofloxacin group

81.8%and 97.3%

respectively in levofloxacin group;the bacterial culture-positive rates were in balofloxacin and levofloxacin group 78%and 77.3%

respectively;the bacterial eradication rates were 95.1%and 94.1%

respectively;the adverse events rate were 8.2%and 8.9%

respectively.There were no significant differences between the two groups(P>0.05).Conclusion:Balofloxacin is as effective and well-tolerated as levofloxacin for the treatment of bacterial infections in urinary system respiratory tract.

关键词

随机对照试验双盲法泌尿道感染细菌感染左氧氟沙星巴洛沙星

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