The influence of passive movement and electric stimulation on the bone BGP and TRACP in rats with denervation

LI Jun-han; et al

doi:10.13406/j.cnki.cyxb.2010.08.015

您当前的位置：

首页 >

文章列表页 >

The influence of passive movement and electric stimulation on the bone BGP and TRACP in rats with denervation

更新时间：2024-01-17

- The influence of passive movement and electric stimulation on the bone BGP and TRACP in rats with denervation
- Journal of Chongqing Medical University Vol. 35, Issue 8, Pages: 1198-1200(2010)
- 作者机构：
  
  1. 绵阳师范学院体育与健康教育学院
  2. 四川省骨科医院住院部
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.08.015
  CLC： R580
- Published：2010，
扫描看全文
[1]李军汉,黄雷.被动运动和电刺激对失神经大鼠骨BGP和TRACP含量的影响[J].重庆医科大学学报,2010,35(08):1198-1200.

LI Jun-han, et al. The influence of passive movement and electric stimulation on the bone BGP and TRACP in rats with denervation. [J]. Journal of Chongqing Medical University 35(8):1198-1200(2010)
[1]李军汉,黄雷.被动运动和电刺激对失神经大鼠骨BGP和TRACP含量的影响[J].重庆医科大学学报,2010,35(08):1198-1200. DOI： 10.13406/j.cnki.cyxb.2010.08.015.

LI Jun-han, et al. The influence of passive movement and electric stimulation on the bone BGP and TRACP in rats with denervation. [J]. Journal of Chongqing Medical University 35(8):1198-1200(2010) DOI： 10.13406/j.cnki.cyxb.2010.08.015.

摘要

目的:实验性研究被动运动和电刺激对废用性骨质疏松的预防作用;方法:切断大鼠坐骨神经和股神经

造成失神经支配大鼠废用性骨质疏松模型

并随机将大鼠分为假手术组、对照组（Denervation group

NCG）、被动运动组（Passive movement groups

PMG）、电刺激组（Electric stimulation group

ESG）和混合干预组（Passive movement and electric stimulation group

PMESG）5组

观察各大鼠骨代谢生化指标骨钙素（Bone gla protein

BGP）和抗酒石酸盐酸性磷酸酶（Tartrate-resistant acid phosphatase

TRACP）的变化;结果:与假手术组比较

各干预组BGP值均呈显著性降低（P<0.01）、TRACP值升高

但差异不具显著性（P>0.05）;与对照组比较

各干预组BGP值均升高

其中混合干预组呈显著性升高（P<0.05）、TRACP值均呈非常显著性降低（P<0.01）。结论:大鼠失神经支配可致骨形成减少、骨吸收增加

电刺激和被动运动治疗可有效抑制大鼠去神经后的骨形成减少以及骨吸收增加

一定程度上表明了被动运动和电刺激对去神经所致大鼠废用性骨质疏松的预防作用。

Abstract

Objective:To discuss the preventive function of passive movement and electric stimulation on rats with disuse osteoporosis. Methods:Through cutting the sciatic nerve and femoral nerve of experimental rats

we made an animal model of disuse osteoporosis

and divided them into five groups:the pseudo operation group

the denervation group(DG)

denervation with passive movement group(PMG)

denervation with electric stimulation group(ESG)

and denervation with passive movement and electric stimulation group(PMESG).Then the changes of biochemistry indicators of bone metabolism were observed in all groups.Results:Compared with sham group

the Bone gla protein(BGP)value in the other groups were markedly lower(P<0.01).The tartrate-resistant acid phosphatas(eTRACP)value in the other groups all had a significant increase

but insignificant in statistics(P>0.05).Compared with DNG

the BGP value in the other groups increased

especially that the BGP in the PMESG was significantly increased(P<0.05)

however

the TRACP value in the other groups all exhibited a very significant reduction(P<0.01).Conclusion:Denervation of rats’sciatic and femoral nerves can make bone formation decrease and bone absorption increase

but passive movement and electric stimulation can inhibit the decrease of bone formation and the increase of bone absorption

which shows that passive movement and electric stimulation can prevent disuse osteoporosis made by denervation on a certain extent.

关键词

失神经被动运动电刺激废用性骨质疏松骨代谢

Keywords

DenervationPassive movementElectric stimulationDisuse osteoporosisbone metabolism

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effects and mechanism of human umbilical cord mesenchymal stem cells on osteoporosis rats by regulating the ratio of osteoprotegerin/receptor activator of nuclear factor-κB ligand

Research advances in the regulatory effect of miR-214 on bone metabolism

Progress of exosomes in bone metabolism,and diagnosis and treatment of bone and joint diseases

Related Author

Ying Wei

Shiwei Liu

Ruixue Duan

Yuxiang Zhao

Nan Li

Yaru Wu

Gu Yan

Guo Jianmin

Related Institution

Teaching and Research Section of Biochemistry and Molecular Biology, College of Basic Medicine, Shanxi Medical University

Department of Endocrinology, Shanxi Bethune Hospital

Department of Endocrinology, Taiyuan Central Hospital

Department of Endocrinology, Guizhou Provincial Peoples Hospital

School of Kinesiology，Shanghai University of Sport

⁰