Tissue dynamic change in the carcinogenesis of the cheek pouch in golden hamster induced by DMBA

MEI Jie; et al

doi:10.13406/j.cnki.cyxb.2010.07.040

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Tissue dynamic change in the carcinogenesis of the cheek pouch in golden hamster induced by DMBA

更新时间：2024-01-17

- Tissue dynamic change in the carcinogenesis of the cheek pouch in golden hamster induced by DMBA
- Journal of Chongqing Medical University Vol. 35, Issue 7, Pages: 1018-1021(2010)
- 作者机构：
  
  重庆医科大学附属第一医院口腔颌面外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.07.040
  CLC： R739.86
- Published：2010，
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[1]梅杰,张国栋,杨凯.DMBA诱导金黄地鼠颊囊癌变的组织学动态变化研究[J].重庆医科大学学报,2010,35(07):1018-1021.

MEI Jie, et al. Tissue dynamic change in the carcinogenesis of the cheek pouch in golden hamster induced by DMBA. [J]. Journal of Chongqing Medical University 35(7):1018-1021(2010)
[1]梅杰,张国栋,杨凯.DMBA诱导金黄地鼠颊囊癌变的组织学动态变化研究[J].重庆医科大学学报,2010,35(07):1018-1021. DOI： 10.13406/j.cnki.cyxb.2010.07.040.

MEI Jie, et al. Tissue dynamic change in the carcinogenesis of the cheek pouch in golden hamster induced by DMBA. [J]. Journal of Chongqing Medical University 35(7):1018-1021(2010) DOI： 10.13406/j.cnki.cyxb.2010.07.040.

摘要

目的:观察分析金黄地鼠在致癌剂二甲基苯并蒽（9

10-Dimethyl-1

2 Benzanthracene

DMBA）作用下颊囊粘膜癌变不同时期在肉眼和光镜下的组织学动态变化过程。方法:用DMBA涂抹金黄地鼠颊囊粘膜

每周3次。在肉眼下动态观察颊囊粘膜的癌变过程;分别在第2、4、6、8、10、12、14周时处死动物

在光镜下动态观察颊囊粘膜癌变过程的显微组织学改变。结果:DMBA涂抹金黄地鼠颊囊粘膜2周时出现单纯增生改变

4周时出现轻度上皮异常增生

6周时出现中度异常增生

8周时出现重度异常增生

部分出现原位癌改变

10周时已发生癌变

实验中得到的癌症模型均为高分化鳞状细胞癌。结论:DMBA诱导的金黄地鼠颊囊粘膜癌和人类口腔鳞状细胞癌（Oral squamous cell carcinoma

OSCC）相似

是研究口腔鳞癌多阶段、多步骤动态发展的理想模型。

Abstract

Objective:To observe and analyze the dynamic changes of hamster’s cheek pouch mucosa in different stages of the carcinogenesis under naked eye and light microscope with the carcinogenic agent dimethyl-benzanthracene(DMBA).Methods:DMBA was painted on hamster’s cheek pouch mucosa

3 times a week.Dynamic observation of the carcinogenesis of cheek pouch mucous membrane was carried out under naked eye;histological dynamic changes in the microstructure of cheek pouch mucosa in the carcinogenesis were observed under light microscope after the animals were killed respectively in the 2nd week

the 4th week

the 6th week

the 10th week

the 12th week and the 14th week.Results:For the cheek pouch mucosa of hamster painted with DMBA

the simple hyperplasia appeared in the 2nd week

the mild epithelial dysplasia in the 4th week

the moderate dysplasia in the 6th week

the severe dysplasia the partial changes of carcinoma in situ in the 8th week and cancer in the 10th week.All cancer models appearing in the experiment belonged to the well-differentiated squamous cell carcinoma.Conclusion:The carcinoma of hamster cheek pouch mucosa induced by DMBA is similar to the human oral squamous cell carcinoma so it is an ideal model for studying the oral squamous cell carcinoma in multi-stage and multi-step dynamic development.

关键词

二甲基苯并葸金黄地鼠颊囊鳞状细胞癌

Keywords

Dimethyl-benzanthranceneGolden hamsterCheek pouchsquamous cellcarcinoma

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