The clinical significance of p16<sup>INK4a</sup> in cervical cytology staging

HUANG Xuan; et al

doi:10.13406/j.cnki.cyxb.2010.07.036

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The clinical significance of p16^INK4a in cervical cytology staging

更新时间：2024-01-17

- The clinical significance of p16^INK4a in cervical cytology staging
- Journal of Chongqing Medical University Vol. 35, Issue 7, Pages: 1026-1028(2010)
- 作者机构：
  
  1. 江汉大学医学院
  2. 江汉大学病理诊断所
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.07.036
  CLC： R737.33
- Published：2010，
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[1]黄萱,陈莹,陈琼霞,邓昊,王成鑫,刘丽江.p16~(INK4a)在子宫颈细胞学分级的临床意义[J].重庆医科大学学报,2010,35(07):1026-1028.

HUANG Xuan, et al. The clinical significance of p16^INK4a in cervical cytology staging. [J]. Journal of Chongqing Medical University 35(7):1026-1028(2010)
[1]黄萱,陈莹,陈琼霞,邓昊,王成鑫,刘丽江.p16~(INK4a)在子宫颈细胞学分级的临床意义[J].重庆医科大学学报,2010,35(07):1026-1028. DOI： 10.13406/j.cnki.cyxb.2010.07.036.

HUANG Xuan, et al. The clinical significance of p16^INK4a in cervical cytology staging. [J]. Journal of Chongqing Medical University 35(7):1026-1028(2010) DOI： 10.13406/j.cnki.cyxb.2010.07.036.

摘要

目的:研究在意义不明的不典型鳞状细胞（Atypical squamous cells of undetermined significance

ASC-US）

不能排除高度上皮内瘤变的不典型鳞状细胞（Atypical squamous cells

cannot exclude high-grade squamous intraepithelial lesion

ASC-H）

低度鳞状上皮内病变（Low-grade squamous intraepithelial lesion

LSIL）

高度鳞状上皮内病变（High-grade squamous intraepithelial lesion

HSIL）中p16INK4a蛋白和HPV16/18的表达水平及意义。方法:应用免疫组织化学技术和原位分子杂交技术

对89例子宫颈细胞涂片样本中p16INK4a蛋白及HPV16/18型DNA进行检测。结果:p16INK4a蛋白阳性率随着子宫颈病变程度的加重而升高

LSIL、HSIL及ASC-H的p16INK4a蛋白阳性率均高于ASC-US（P<0.05）;ASC-US和LSIL的p16INK4a阳性表达与HPV16/18阳性表达无差异性;LSIL和ASC-US的HPV16/18阳性表达无差异性。结论:子宫颈细胞涂片样本中p16INK4a蛋白检测能协助子宫颈细胞学诊断分级

尤其对于ASC-US的病例

需同时做p16INK4a免疫组织化学检查

以帮助临床医生选择恰当的处理方式。

Abstract

Objective:To investigate the expression and significance ofp16INK4a and HPV16/18 in atypical squamous cells of undetermined significance(ASC-US)

atypical squamous cells

cannot exclude high-grade squamous intraepithelial lesion(ASC-H)

low-grade squamous intraepithelial lesion(LSIL)

high-grade squamous intraepithelial lesion(HSIL).Methods:p16INK4a and HPV16/18 DNA in thin-layer slides from 89 specimens were detected by immunohistochemistry and the insitu hybridization.Results:A positive correlation was found between the positive rate of p16INK4a and cervical disease progression

the positive rate of p16INK4a in LSIL

HSIL

ASC-H were higher than ASC-US(P<0.05);There were not variability between the positive rate of p16INK4a and HPV16/18 DNA in ASC-US and LSIL; p16INK4a positive rate in ASC-US was not related with p16INK4a positive rate in LSIL.Conclusion:Detecting p16INK4a in thin-layer slides could help staging in cervical cytology

p16INK4a should be detected by immunohistochemistry for ASC-US

which could help clinical doctor choose a curative treatment.

关键词

p16INK4aHPV16/18型子宫颈细胞学

Keywords

p16INK4aHPV16/18Cervical cytology

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The clinical significance of p16INK4a in cervical cytology staging

DOI：10.13406/j.cnki.cyxb.2010.07.036

摘要

Abstract

关键词

Keywords

references

The clinical significance of p16^INK4a in cervical cytology staging