Expression and significance of Ki-67,MMP-2 and MMP-7 in CIN and cervical cancer

TENG Yan-yi; et al

doi:10.13406/j.cnki.cyxb.2010.07.034

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Expression and significance of Ki-67,MMP-2 and MMP-7 in CIN and cervical cancer

更新时间：2024-01-17

- Expression and significance of Ki-67,MMP-2 and MMP-7 in CIN and cervical cancer
- Journal of Chongqing Medical University Vol. 35, Issue 7, Pages: 989-991(2010)
- 作者机构：
  
  1. 遵义医学院第三附属医院妇产科
  2. 遵义医学院附属医院病理科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.07.034
  CLC： R737.33
- Published：2010，
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[1]滕燕伊,刘晓云,郑洪,伍小智.Ki-67、MMP-7、MMP-2在宫颈CIN和宫颈癌中的表达及意义[J].重庆医科大学学报,2010,35(07):989-991.

TENG Yan-yi, et al. Expression and significance of Ki-67,MMP-2 and MMP-7 in CIN and cervical cancer. [J]. Journal of Chongqing Medical University 35(7):989-991(2010)
[1]滕燕伊,刘晓云,郑洪,伍小智.Ki-67、MMP-7、MMP-2在宫颈CIN和宫颈癌中的表达及意义[J].重庆医科大学学报,2010,35(07):989-991. DOI： 10.13406/j.cnki.cyxb.2010.07.034.

TENG Yan-yi, et al. Expression and significance of Ki-67,MMP-2 and MMP-7 in CIN and cervical cancer. [J]. Journal of Chongqing Medical University 35(7):989-991(2010) DOI： 10.13406/j.cnki.cyxb.2010.07.034.

摘要

目的:检测Ki-67、MMP-7、MMP-2在宫颈CIN及宫颈癌中的表达情况

探讨Ki-67、MMP-7、MMP-2与宫颈癌的发生、发展

增殖和侵袭转移之间的关系。方法:采用免疫组化S-P法和图像分析技术检测Ki-67、MMP-7、MMP-2在已确诊的50例宫颈癌（Invasive cervical cancer

ICC）、23例宫颈上皮内瘤样变（Cervical intraepithelial neoplasm

CIN）和正常宫颈（Normal cervical epithelium

NCE）对照20例的表达情况。结果:50例宫颈癌中ki-67、MMP-7、MMP-2的阳性表达分别为72.00%、78.00%、76.00%;CIN组ki-67、MMP-7、MMP-2的阳性表达分别为47.83%、60.87%、56.52%;正常对照组ki-67、MMP-7、MMP-2的阳性表达分别为10、0、0;Ki-67在子宫颈癌组和CIN组明显高于正常宫颈上皮组

在腺癌中的表达高于鳞癌（P<0.05）

在CINⅠ和CINⅡ、CINⅢ中表达无明显差异

在低分化癌的表达明显高于高分化癌（P<0.05）

在淋巴结转移组中的表达明显高于非淋巴结转移组（P<0.05）;MMP-7、MMP-2在宫颈癌组织中的表达水平高于CIN及正常宫颈组织（P<0.01）

MMP-7、MMP-2的表达与宫颈癌的病理类型及分化无关

在淋巴结转移组中表达高于非淋巴转移组。结论:Ki-67、MMP-2、MMP-7与宫颈癌肿瘤细胞的侵袭转移行为相关。

Abstract

Objective:To investigate the Ki-67

MMP-7

MMP-2 expression in cervical intraepithelial neoplasm(CIN)and cervical cancer

with the aim of evaluating their association with the development

aggressiveness and lymph node metastasis.Methods:The immunohistochemical S-P method and image analysis were used to detect Ki-67

MMP-7

MMP-2 expression in 50 cases with cervical cancer

23 cases with CIN and 20 cases of normal control.Results:Ki-67

MMP-7

MMP-2 were mainly expressed in the membrane and /or cytoplasm in tumor cells.The positive rate of Ki-67

MMP-7and MMP-2 were 72.00%

78.00%

76.00%in carcinoma

47.83%

60.87%

56.52%in CIN lesions

0 in normal cervical tissues respectively.Expression rate in ICC was obviously higher than that in control group(P<0.01).The adencarcinoma(AC)group was higher than squamous cell carcinoma group(SCC)groups(P<0.05).No difference was found between CINⅠand CINⅡ-Ⅲin their ki-67 expression(P>0.05).High grade diseases and those with lymph node involved presented with higher ki-67 expression than low grade diseases and those without lymph node metastasis(P<0.05).Similarly

cervical cancer displayed much higher MMP-7 and MMP-2 expression as compared with CIN and normal controls(P<0.01).Pathological features or histological differentiation have no impact upon their expression level.However

those with lymph node involved demonstrated higher MMP-7 and MMP-2 expression than those without.Conclusion:The expression of ki-67

MMP-2 and MMP-7 was associated with the aggressive and metastatic behavior of tumor cells in CIN and invasive cervical cancer.

关键词

宫颈癌CINKi-67MMP-2MMP-7

Keywords

cervical cancerCINKi-67MMP-2MMP-7

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