Comparison of transforming growth factor-β<sub>1</sub> expression and therapeutic effects on tibia and fibular fracture with two different fixation methods

FU Jie

doi:10.13406/j.cnki.cyxb.2010.07.018

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Comparison of transforming growth factor-β₁ expression and therapeutic effects on tibia and fibular fracture with two different fixation methods

更新时间：2024-01-17

- Comparison of transforming growth factor-β₁ expression and therapeutic effects on tibia and fibular fracture with two different fixation methods
- Journal of Chongqing Medical University Vol. 35, Issue 7, Pages: 1098-1100(2010)
- 作者机构：
  
  重庆市第六人民医院骨科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.07.018
  CLC： R687.3
- Published：2010，
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[1]傅捷.2种固定方法治疗胫腓骨骨折对转化生长因子-β_1表达影响及疗效比较[J].重庆医科大学学报,2010,35(07):1098-1100.

FU Jie. Comparison of transforming growth factor-β₁ expression and therapeutic effects on tibia and fibular fracture with two different fixation methods. [J]. Journal of Chongqing Medical University 35(7):1098-1100(2010)
[1]傅捷.2种固定方法治疗胫腓骨骨折对转化生长因子-β_1表达影响及疗效比较[J].重庆医科大学学报,2010,35(07):1098-1100. DOI： 10.13406/j.cnki.cyxb.2010.07.018.

FU Jie. Comparison of transforming growth factor-β₁ expression and therapeutic effects on tibia and fibular fracture with two different fixation methods. [J]. Journal of Chongqing Medical University 35(7):1098-1100(2010) DOI： 10.13406/j.cnki.cyxb.2010.07.018.

摘要

目的:检测加压钢板和交锁髓内钉固定胫腓骨骨折后（Transforming growth factor-β1

TGF-β1）表达的改变

评价2种治疗方式对骨折愈合的影响。方法:117例非严重胫腓骨骨折患者随机分组

分别采用加压钢板和交锁髓内钉固定治疗

采用ELISA法在手术治疗后1d、7d、30d和90d分别检测TGF-β1的含量

并和手术后30d时的临床疗效相比较。结果:手术治疗后7dTGF-β1含量较1d有所上升

而至术后30d到9d

TGF-β1含量又逐渐下降。同时间点2组间比较

加压钢板固定组TGF-β1含量均较交锁髓内钉固定组TGF-β1含量低（P<0.01）。术后3月时

加压钢板固定组疗效优良率77.6%

低于交锁髓内钉固定组的91.5%（χ2=4.366

P=0.037）。而2组的并发症发生率相当（χ2=0.068

P=0.794）。结论:交锁髓内钉固定治疗胫腓骨骨折优于加压钢板固定

TGF-β1表达的差异在其中起到一定的作用。

Abstract

Objective:To detect the expression of TGF-β1 in tibia and fibula fracture with two methods of compression plate fixation and intramedullary nail fixation

and to evaluate their therapeutic effects.Methods:117 patients with non severe tibia and fibula fractures were separated into two groups.One group received pressurized plates fixation for treatment

the other received intramedullary nail fixation.On 1

30 and 90 days after surgery

TGF-β1 was detected by ELISA

and on 30 days after surgery the clinical efficacy were also assessed. Results:The TGF-β1 content increased on 7 days as compared with that on 1 days after surgery

and the TGF-β1 content gradually decreased at on 30 to 90 days after surgery.The TGF-β1 content in compression plate fixation group were lower than that in intramedullary nailing group every points of four days(P<0.01).The excellent efficacy was 77.6%in the compression plate fixation group 3 months after surgery

which was lower than 91.5%in the intramedullary nailing group(χ2=4.366

P=0.037).But thecomplication rate in two groups was the same(χ2=0.068

P=0.794).Conclusion:The interlocking intramedullary nail fixation for tibia and fibula fracture has a better clinical efficacy than compression plate fixation

and the increased TGF-β1 expression may play a important role.

关键词

胫腓骨骨折加压钢板固定交锁髓内钉固定TGF-β1疗效

Keywords

Tibia and fibula fracturesCompression plate dixationIntramedullary nailing fixationTGF-β1Clinical efficacy

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Comparison of transforming growth factor-β1 expression and therapeutic effects on tibia and fibular fracture with two different fixation methods

DOI：10.13406/j.cnki.cyxb.2010.07.018

摘要

Abstract

关键词

Keywords

references

Comparison of transforming growth factor-β₁ expression and therapeutic effects on tibia and fibular fracture with two different fixation methods