Effects of angiotensin Ⅳ on the hippocampus neuronal apoptosis and the cognitive function of diabetic rats

ZHANG Dong-ming; et al

doi:10.13406/j.cnki.cyxb.2010.07.017

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Effects of angiotensin Ⅳ on the hippocampus neuronal apoptosis and the cognitive function of diabetic rats

更新时间：2024-01-17

- Effects of angiotensin Ⅳ on the hippocampus neuronal apoptosis and the cognitive function of diabetic rats
- Journal of Chongqing Medical University Vol. 35, Issue 7, Pages: 978-981(2010)
- 作者机构：
  
  重庆医科大学附属第一医院老年科内分泌组
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.07.017
  CLC： R587.1
- Published：2010，
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[1]张栋珉,肖谦,张颖.血管紧张素Ⅳ对糖尿病大鼠海马神经元凋亡及其认知功能的影响[J].重庆医科大学学报,2010,35(07):978-981.

ZHANG Dong-ming, et al. Effects of angiotensin Ⅳ on the hippocampus neuronal apoptosis and the cognitive function of diabetic rats. [J]. Journal of Chongqing Medical University 35(7):978-981(2010)
[1]张栋珉,肖谦,张颖.血管紧张素Ⅳ对糖尿病大鼠海马神经元凋亡及其认知功能的影响[J].重庆医科大学学报,2010,35(07):978-981. DOI： 10.13406/j.cnki.cyxb.2010.07.017.

ZHANG Dong-ming, et al. Effects of angiotensin Ⅳ on the hippocampus neuronal apoptosis and the cognitive function of diabetic rats. [J]. Journal of Chongqing Medical University 35(7):978-981(2010) DOI： 10.13406/j.cnki.cyxb.2010.07.017.

摘要

目的:观察血管紧张素Ⅳ（Angiotensin Ⅳ

AngⅣ）对糖尿病大鼠海马神经元凋亡及其认知功能的影响。方法:38只SD大鼠随机分为正常对照组、糖尿病组和糖尿病+AngⅣ组

建立STZ糖尿病大鼠模型

Morris水迷宫测试大鼠学习和记忆能力

免疫组化观察大鼠海马凋亡调节因子Bcl-xl的表达

同时用原位末端标记法检测海马神经元凋亡。结果:糖尿病+AngⅣ组大鼠学习和记忆成绩明显优于糖尿病组（P<0.05）

其海马Bcl-xl表达也明显增高（P<0.05）

而且其海马神经元凋亡明显减少。结论:AngⅣ对糖尿病大鼠认知功能有改善作用

机制可能与上调Bcl-xl的表达保护海马神经元凋亡有关。

Abstract

Objective:To explore the effects of angiotens in Ⅳ on the hippocampus neuronal apoptosis and the cognitive function of diabetic rats.Methods:38 SD male rats were divided into normal group

diabetic model group and angiotensin Ⅳ treatment group randomly.Streptozotocin-diabetic rat model was established and learning and memory behaviors were investigated using a spatial version of the Morris water maze test.The expression of Bcl-xl of all rats was examined with immunohistochemical method.Meanwhile

the hippocampal neuronal apoptosis were measured by TUNEL.Results:Learning and memory grade in the angiotensin Ⅳ treatment group were better than diabetic model group(P<0.05).The changes of Bcl-xl in hippocampus significantly increased in the angiotensin Ⅳ treatment group and the number of apoptotic neurons of the hippocampus was decreased remarkably(P<0.05).Conclusion:Angiotensin Ⅳ could improve cognitive ability in diabetic rats by increasing the expression of Bcl-xl to protect hippocampus neuronal apoptosis.

关键词

血管紧张素Ⅳ糖尿病凋亡认知功能

Keywords

Angiotensin Ⅳdiabetes mellitusapoptosisCognition

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