Toxic effects of artemisia aqueous extract on general reproduction in male mice

ZHU Mei; et al

doi:10.13406/j.cnki.cyxb.2010.07.004

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Toxic effects of artemisia aqueous extract on general reproduction in male mice

更新时间：2024-01-17

- Toxic effects of artemisia aqueous extract on general reproduction in male mice
- Journal of Chongqing Medical University Vol. 35, Issue 7, Pages: 1029-1031(2010)
- 作者机构：
  
  1. 四川泸州医学院生理教研室
  2. 西安市胸科医院外科
  3. 重庆医科大学神经科学研究中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.07.004
  CLC： R285.5
- Published：2010，
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[1]竹梅,张会军,王莎莉.青蒿水提物对雄性小鼠一般生殖毒性的实验研究[J].重庆医科大学学报,2010,35(07):1029-1031.

ZHU Mei, et al. Toxic effects of artemisia aqueous extract on general reproduction in male mice. [J]. Journal of Chongqing Medical University 35(7):1029-1031(2010)
[1]竹梅,张会军,王莎莉.青蒿水提物对雄性小鼠一般生殖毒性的实验研究[J].重庆医科大学学报,2010,35(07):1029-1031. DOI： 10.13406/j.cnki.cyxb.2010.07.004.

ZHU Mei, et al. Toxic effects of artemisia aqueous extract on general reproduction in male mice. [J]. Journal of Chongqing Medical University 35(7):1029-1031(2010) DOI： 10.13406/j.cnki.cyxb.2010.07.004.

摘要

目的:观察青蒿水提物对雄性小鼠生殖能力的影响。方法:采用一般生殖毒性实验

80只雄性昆明小鼠随机分为生理盐水组、青蒿水提物低剂量组（20mg/kg）、中剂量（100mg/kg）和高剂量组（500mg/kg）。雄鼠连续腹腔给药60d

然后按雌雄比例2∶1合笼喂养交配、处死

检测青蒿水提物对各组雄鼠的交配率、睾丸、精子数量、活动精子百分率和畸形率的影响以及睾丸组织病理学变化。结果:500mg/kg青蒿水提物对前述所检测的生育指标无明显影响。结论:青蒿水提物对雄鼠的生殖功能无明显毒性作用。

Abstract

Objective:To observe the toxic effects of artemisia aqueous extract on the ability of reproduction in male mice.Methods:Mice were randomly divided into 0

100 and 500 mg/kg dose groups and administered intraperitoneally for 60 days then mated and exeduted. The coefficient of testicle and epididymis

fertility index

sperm

the percentage of motile sperm

deformity of sperm and histopathological changes of testicle were detected.Results:The concentrations of artemisia aqueous extract used in this study have no significant influence on the aforementioned parameters.Conclusion:Reproductive functions of male mice does not obviously impaired by artemisia aqueous extract.

关键词

青蒿水提物雄性小鼠生殖毒性

Keywords

Artemisia aqueous extractMale micereproductive toxicity

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