FAT regiment for patients with relapsed,refractory acute leukemia

LUO Yun; et al

doi:10.13406/j.cnki.cyxb.2010.06.042

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FAT regiment for patients with relapsed,refractory acute leukemia

更新时间：2024-01-17

- FAT regiment for patients with relapsed,refractory acute leukemia
- Journal of Chongqing Medical University Vol. 35, Issue 6, Pages: 948-950(2010)
- 作者机构：
  
  重庆医科大学附属第二医院血液科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.06.042
  CLC： R733.71
- Published：2010，
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[1]罗云,娄世锋,陈姝,陈林,周慷,邓建川.FAT方案治疗复发/难治急性白血病临床观察[J].重庆医科大学学报,2010,35(06):948-950.

LUO Yun, et al. FAT regiment for patients with relapsed,refractory acute leukemia. [J]. Journal of Chongqing Medical University 35(6):948-950(2010)
[1]罗云,娄世锋,陈姝,陈林,周慷,邓建川.FAT方案治疗复发/难治急性白血病临床观察[J].重庆医科大学学报,2010,35(06):948-950. DOI： 10.13406/j.cnki.cyxb.2010.06.042.

LUO Yun, et al. FAT regiment for patients with relapsed,refractory acute leukemia. [J]. Journal of Chongqing Medical University 35(6):948-950(2010) DOI： 10.13406/j.cnki.cyxb.2010.06.042.

摘要

目的:研究氟达拉滨（Flu）、阿糖胞苷（Ara-C）及拓扑替康（Top）联合应用（FAT方案）治疗复发/难治急性白血病的疗效和不良反应。方法:Flu25mg（/m

·d）静脉滴注30min

;Ara-C1

g（/m

·d）静脉滴注4h

;Top1.2mg（/m

·d）静脉滴注2h

;在WBC

1×10

个/L时用G-CSF5μg（/kg·d）直至WBC

4×10

个/L共治疗9例复发/难治急性白血病。结果:9例患者6例获得完全缓解

1例部分缓解

2例无效;毒副反应包括骨髓抑制、发热、腹泻、轻度肝损伤等。结论:FAT方案治疗复发难治急性白血病有较好的疗效

且毒副作用可以耐受

可用于治疗其他化疗方案无效的复发/难治急性白血病

为患者赢得了进行造血干细胞移植的时机。

Abstract

Objective:To observe the therapeutic effects and side effects of FAT (fludarabine

cytarabin

and topotecan)regimen for relapsed or refractory acute leukemia.Methods:The regiment consisted of Flu 25 mg/ (m2·d)iv 30 min

from dl to d5;Ara-C 1.0 or 2 g/ (m2·d)iv 4 h

from dl to d5

and Top 1.2 mg/(m2·d)iv 2h

form d1 to d3. G-CSF was to employ from WBC<1.0×109/L until the WBC> 4×109/L .9 cases of refractory or relapsed acute leukemia were treated with this regimen.Results:In all the 9 cases of leukemia

6 cases achieved the complete remission (6/9)

1 case had achieved partly remission and 2 cases had no response .The main toxicities were myelosupression

fever

diarrhea and slight hepatic injury .Conclusion:FAT regiment shows favorable outcome for refractory or relapsed acute leukemia

and side effects can be tolerance .It can be employed for the patients with refractory or relapsed acute leukemia who had no response to the first line regimen or other salvage regimens and get a chance for further hematopoietic stem cell transplantation.

关键词

急性白血病氟达拉滨联合化疗

Keywords

acute leukemiafludarabineCombined chemotherapy

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