Pathological changes of transplanted rabbit breast tumor treated with high intensity focused ultrasound

ZOU Wen-bing; et al

doi:10.13406/j.cnki.cyxb.2010.06.037

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Pathological changes of transplanted rabbit breast tumor treated with high intensity focused ultrasound

更新时间：2024-01-17

- Pathological changes of transplanted rabbit breast tumor treated with high intensity focused ultrasound
- Journal of Chongqing Medical University Vol. 35, Issue 6, Pages: 829-832(2010)
- 作者机构：
  
  1. 重庆医科大学生物医学工程系超声医学工程重庆市市级重点实验室重庆市生物医学工程学重点实验室
  2. 重庆医科大学基础医学院病理学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.06.037
  CLC： R737.9
- Published：2010，
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[1]邹文兵,牛陵川,向理科,朱辉,王智彪.高强度聚焦超声治疗兔乳腺移植瘤的病理变化[J].重庆医科大学学报,2010,35(06):829-832.

ZOU Wen-bing, et al. Pathological changes of transplanted rabbit breast tumor treated with high intensity focused ultrasound. [J]. Journal of Chongqing Medical University 35(6):829-832(2010)
[1]邹文兵,牛陵川,向理科,朱辉,王智彪.高强度聚焦超声治疗兔乳腺移植瘤的病理变化[J].重庆医科大学学报,2010,35(06):829-832. DOI： 10.13406/j.cnki.cyxb.2010.06.037.

ZOU Wen-bing, et al. Pathological changes of transplanted rabbit breast tumor treated with high intensity focused ultrasound. [J]. Journal of Chongqing Medical University 35(6):829-832(2010) DOI： 10.13406/j.cnki.cyxb.2010.06.037.

摘要

目的:观察兔乳腺移植瘤经高强度聚焦超声（High intensity focused ultrasound

HIFU）治疗后的病理变化。方法:42只实验兔随机分成HIFU组（n=35）、对照组（n=7）

HIFU组在B超监控下接受HIFU治疗

辐照后采集标本行病理检查。结果:HIFU辐照后靶区呈灰白色;即刻HE染色显示肿瘤细胞形态、排列与对照组无明显变化;电镜显示细胞膜、核膜断裂

细胞器破坏

胞质内出现无膜结构大小不等的空泡;琥珀酸脱氢酶（Succinate dehydrogenase

SDH）、增殖细胞核抗原（Proliferating cell nuclear antigen

PCNA）阴性表达

提示肿瘤细胞已死亡;随着时间的延长坏死肿瘤组织逐渐液化吸收

纤维化。结论:HIFU能有效地灭活肿瘤细胞

为HIFU开展治疗乳腺癌的临床应用提供参考价值。

Abstract

Objective:To observe the histopathological changes of transplanted rabbit breast tumor treated with high intensity focused ultrasound (HIFU).Methods:Forty-two experimental rabbits were divided into HIFU group (n=35)and control group(n=7)

HIFU ablation was completely performed in the HIFU group with ultrasound imaging guidance

and the pathological changes were examined immediately and on 1st

3rd

7th

14th

21st

28th day after HIFU treatment.Results:The target area of tumor appeared gray immediately after HIFU treatment;the morphology and arrangement of the cellular nucleus showed no obvious alteration in HE stained sections after HIFU ablation;however

electron microscopy revealed that the cellular membrane and nuclear membrane was rupturing

cell organelle destructed and appearance of vacuolus without membrane in cytoplasm;Enzyme histochemical staining showed that the succinate dehydrogenase (SDH)in target area of tumor disappeared

also the proliferating cell nuclear antigen (PCNA)was negative examined by using immunohistochemical staining

suggesting the death of tumor cells;The coagulative tissue got liquefied and absorbed with the extension of time

then it was substituted by fibrous tissue finally. Conclusion:HIFU can effectively destroy the transplanted rabbit breast tumor

it provided referred value for clinical application of HIFU in the treatment of breast cancer.

关键词

高强度聚焦超声消融乳腺肿瘤治疗病理学

Keywords

High intensity focused ultrasound ablationBreast neoplasmstherapypathology

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