The effect of mouse uterine decidualization on NK cell distribution and maturation

ZHANG Li; et al

doi:10.13406/j.cnki.cyxb.2010.06.031

您当前的位置：

首页 >

文章列表页 >

The effect of mouse uterine decidualization on NK cell distribution and maturation

更新时间：2024-01-17

- The effect of mouse uterine decidualization on NK cell distribution and maturation
- Journal of Chongqing Medical University Vol. 35, Issue 6, Pages: 810-812(2010)
- 作者机构：
  
  南昌大学医学院生理学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.06.031
  CLC： R714
- Published：2010，
扫描看全文
[1]张莉,徐宏,张保平,彭婧,况海斌.小鼠子宫蜕膜化对uNK细胞分布及成熟性的影响[J].重庆医科大学学报,2010,35(06):810-812.

ZHANG Li, et al. The effect of mouse uterine decidualization on NK cell distribution and maturation. [J]. Journal of Chongqing Medical University 35(6):810-812(2010)
[1]张莉,徐宏,张保平,彭婧,况海斌.小鼠子宫蜕膜化对uNK细胞分布及成熟性的影响[J].重庆医科大学学报,2010,35(06):810-812. DOI： 10.13406/j.cnki.cyxb.2010.06.031.

ZHANG Li, et al. The effect of mouse uterine decidualization on NK cell distribution and maturation. [J]. Journal of Chongqing Medical University 35(6):810-812(2010) DOI： 10.13406/j.cnki.cyxb.2010.06.031.

摘要

目的:探讨子宫自然杀伤（Uterine natural killer

uNK）细胞在小鼠妊娠早期子宫的分布及其调节。方法:用uNK细胞特异性的DBA-lectin抗体

对正常妊娠、延缓着床和人工诱导蜕膜化子宫壁内uNK细胞进行免疫组织化学标记。结果:在胚胎着床前

DBA-lectin染色主要分布于一些血管内皮细胞。至妊娠第5d

胚胎着床以后

NK细胞分布于子宫的系膜侧基质中

主要是一些小的、未成熟的uNK细胞。至妊娠第7、8d时

NK细胞分布于子宫的系膜侧蜕膜中

且逐渐变大和成熟

胞浆颗粒变得越来越致密。在人工诱导蜕膜化模型中

uNK细胞在子宫内膜的分布及成熟性与正常妊娠过程基本相似。结论:在妊娠早期

小鼠uNK细胞分布及成熟性主要受子宫内膜蜕膜化的影响。

Abstract

Objective:To investigate the distribution and regulation of uterine NK cells in mouse uterus during early pregnancy. Methods:Using a unique uNK cell marker

Dolichos biflorus agglutinin (DBA) lectin

to localize NK cells in uterus of normal pregnancy

delayed implantation and artificially induced decidualization. Results:DBA staining is mainly distributed in some vascular endothelial cells during embryo pre-implantation. In D5 of pregnancy after embryo implantation

NK cells were distributed in the stroma of uterine mesometrial pole

with round

immature and small lymphocyte-like cells. During D7 and D8 of pregnancy

the immunostaining results showed that uNK cells were increasingly accumulated in the mesometrial pole of implantation sites

with their morphology changing from small round cells with scattered cytoplasm to large and mature cells with heavy cytoplasmic granules. In the artificially induced decidualization model

the distribution and maturity of NK cells are similar to those of the normal pregnancy in the mouse uteri. Conclusion:The distribution and maturation of uterine NK cells are dependent of uterine decidualization in mouse early pregnancy.

关键词

子宫自然杀伤细胞子宫妊娠早期蜕膜化

Keywords

uNK celluterusEarly pregnancydecidualization

references

Views

226

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

DWI of the normal uterine myometrium:spatial and temporal change of apparent diffusion coefficient values

MRI manifestation of the uterus in nulliparous healthy women at childbearing age

Nme2 participates in decidualization in mice stromal cells

Stomatin-like protein 2(SLP-2) regulates cell proliferation and differenation in endometrial stromal cell line T-HESC

MRI Study of Normal Rhesus Uterus

Related Author

Chen Bo

Lyu Furong

Lyu Fajin

Xiao Zhibo

Sheng Bo

Shi Xiaolin

Chen Bo

Xiao Zhibo

Related Institution

Department of Radiology,The First Affiliated Hospital of Chongqing Medical University

Laboratory of the Reproductive Biology, School of Public Health and Management,Chongqing Medical University

Department of Comprehensive Herbal Medicine,Traditional Chinese Medicine School,Chongqing Medical University

Laboratory of Reproductive Biology,School of Public Health and Management,Chongqing Medical University

Department of Radiology,College of Clinical Medicine,Chongqing Medical University

⁰