The efficacy and safety of recombinant human insulin Injection(Usiling R)in intensive treatment of type 2 diabetes

ZENG Jun; et al

doi:10.13406/j.cnki.cyxb.2010.06.025

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The efficacy and safety of recombinant human insulin Injection(Usiling R)in intensive treatment of type 2 diabetes

更新时间：2024-01-17

- The efficacy and safety of recombinant human insulin Injection(Usiling R)in intensive treatment of type 2 diabetes
- Journal of Chongqing Medical University Vol. 35, Issue 6, Pages: 945-947(2010)
- 作者机构：
  
  1. 重庆医科大学附属第二医院内分泌科
  2. 重庆市九龙坡区第二人民医院内科
  3. 重庆医科大学检验系临床生化教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.06.025
  CLC： R587.1
- Published：2010，
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[1]曾俊,杨刚毅,徐秋,李伶,李钶,李生兵,陈文雯.重组人胰岛素注射液(优思灵R)强化治疗2型糖尿病的疗效和安全性[J].重庆医科大学学报,2010,35(06):945-947.

ZENG Jun, et al. The efficacy and safety of recombinant human insulin Injection(Usiling R)in intensive treatment of type 2 diabetes. [J]. Journal of Chongqing Medical University 35(6):945-947(2010)
[1]曾俊,杨刚毅,徐秋,李伶,李钶,李生兵,陈文雯.重组人胰岛素注射液(优思灵R)强化治疗2型糖尿病的疗效和安全性[J].重庆医科大学学报,2010,35(06):945-947. DOI： 10.13406/j.cnki.cyxb.2010.06.025.

ZENG Jun, et al. The efficacy and safety of recombinant human insulin Injection(Usiling R)in intensive treatment of type 2 diabetes. [J]. Journal of Chongqing Medical University 35(6):945-947(2010) DOI： 10.13406/j.cnki.cyxb.2010.06.025.

摘要

目的:以诺和灵R为对照

采用随机对照临床试验

说明预混人胰岛素注射液优思灵R治疗2型糖尿病（Type2 diabetes mellitus

T2DM）的有效性和安全性。方法:共入选44例T2DM患者

按1∶1的比例随机分为优思灵R组（n=22）和诺和灵R组（n=22）

治疗前和12周后分别测定受试者糖化血红蛋白（HbA1c）、空腹血糖（FPG）、餐后2h血糖（2hPG）水平

肝肾功能、体重和BMI值变化以及不良反应发生率。结果:治疗12周后

2组患者HbA1c、FPG和2hPG水平均明显降低（P≤0.05）

但两组间无显著性差异（P>0.05）。治疗前后两组间血脂、肝肾功能、体重和BMI值无显著性差异（P>0.05）。结论:与诺和灵R相比

优思灵R在治疗T2DM方面具有一定的有效性和安全性

并具有良好的耐受性。

Abstract

Objective:To compare the efficacy and safety of Usiling R and Novolin R in treatment of type 2 diabetes with the randomized controlled clinical trial. Methods:44 cases of T2DM were randomized into two groups (1∶1) treated with Usiling R versus Novolin R

and compared the HbA1c

FPG

2 hPG level

liver and kidney function

body weight

BMI

and the incidence of adverse events before and after 12 weeks of treatment. Results:Compared with pretreatment

at the end of 12 weeks’treatment

the decreased values of HbA1c

FPG and 2 hPG were all proved significantly in both Usiling R group and NovolinR group (P≤0.05)

but the changes of HbA1c

FPG and 2 hPG from baseline to endpoint were similar between the two treatment groups (P>0.05). The impact on blood lipids

liver and kidney function

body weight and BMI values had no significant difference

and between the two groups also had no significant difference(P>0.05). Conclusion:Usiling R and Novolin R have similar efficacy and safety profiles in the treatment of diabetic patients.

关键词

2型糖尿病优思灵R有效性安全性

Keywords

T2DMUsiling Refficacysafety

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