The minimal local anesthetic dose of bupivacaine for caesarean section in combined spinal-epidural anesthesia determined by up-and-down method

LI Xiao-xia; et al

doi:10.13406/j.cnki.cyxb.2010.05.020

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The minimal local anesthetic dose of bupivacaine for caesarean section in combined spinal-epidural anesthesia determined by up-and-down method

更新时间：2024-01-17

- The minimal local anesthetic dose of bupivacaine for caesarean section in combined spinal-epidural anesthesia determined by up-and-down method
- Journal of Chongqing Medical University Vol. 35, Issue 5, Pages: 753-755(2010)
- 作者机构：
  
  1. 重庆医科大学附属第二医院麻醉科
  2. 武警重庆总队医院麻醉科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.05.020
  CLC： R614
- Published：2010，
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[1]李晓霞,郎中兵,龙海林,陈楠,徐昆.腰硬联合麻醉用于剖宫产时布比卡因腰麻剂量的探讨[J].重庆医科大学学报,2010,35(05):753-755.

LI Xiao-xia, et al. The minimal local anesthetic dose of bupivacaine for caesarean section in combined spinal-epidural anesthesia determined by up-and-down method. [J]. Journal of Chongqing Medical University 35(5):753-755(2010)
[1]李晓霞,郎中兵,龙海林,陈楠,徐昆.腰硬联合麻醉用于剖宫产时布比卡因腰麻剂量的探讨[J].重庆医科大学学报,2010,35(05):753-755. DOI： 10.13406/j.cnki.cyxb.2010.05.020.

LI Xiao-xia, et al. The minimal local anesthetic dose of bupivacaine for caesarean section in combined spinal-epidural anesthesia determined by up-and-down method. [J]. Journal of Chongqing Medical University 35(5):753-755(2010) DOI： 10.13406/j.cnki.cyxb.2010.05.020.

摘要

目的:探讨腰硬联合麻醉（Combined spinal-epidural anesthesia

CSEA）用于剖宫产时

布比卡因的腰麻剂量。方法:采用序贯法设计

选取34例合乎标准的产妇按设定的剂量梯度及方案给药

并连续监测血压、心率、血氧饱和度及心电图

观察麻醉效果（镇痛、肌松）

有无不良反应以及进行新生儿评分。结果:腰硬联合麻醉用于剖宫产时

布比卡因腰麻的最低有效剂量为5.03mg（4.1～5.1mg）

ED90及ED95分别为7.15、7.89mg。结论:腰硬联合麻醉时用于剖宫产时

欲使大多数产妇麻醉效果好而且临床应用方便可行的布比卡因的腰麻剂量为7.5mg。

Abstract

Objective:To investigate the minimal local anesthetic dose(MLAD) of bupivacaine for caesarean section in combined spinal-epidural anesthesia(CSEA).Methods:Designed by up-and-down

34 parturients who met the standards were given bupivacaine as planned dose gradient.Hemodynamics were monitored continuously

untoward effects were observed and APGAR of the neonates were given.Results:The MLAD of bupivacaine which is used in CSEA for caesarean section is 5.03 mg(4.1～5.1 mg)

and that of ED90 and ED95 are 7.15 mg

7.89 mg respectively.Conclusion:The clinical easy to use dose of bupivacaine is 7.5 mg which is used in CSEA for most parturients.

关键词

腰硬联合麻醉剖宫产布比卡因局麻药最低有效剂量

Keywords

Combined spinal-epidural anesthesiaCaesarean SectionBupivacaineMinimal local anesthetic dose

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