The effect of chronic intermittent hypoxia on blood glucose and pancreatic islets B-cell ultrastructure in rats

GUI Ming-cai; et al

doi:10.13406/j.cnki.cyxb.2010.05.008

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The effect of chronic intermittent hypoxia on blood glucose and pancreatic islets B-cell ultrastructure in rats

更新时间：2024-01-17

- The effect of chronic intermittent hypoxia on blood glucose and pancreatic islets B-cell ultrastructure in rats
- Journal of Chongqing Medical University Vol. 35, Issue 5, Pages: 681-684(2010)
- 作者机构：
  
  重庆医科大学附属第一医院耳鼻咽喉科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.05.008
  CLC： R363
- Published：2010，
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[1]桂明才,李兵,邱昌明,张涛,赵维.慢性间歇性缺氧对大鼠血糖及其胰岛B细胞超微结构的影响[J].重庆医科大学学报,2010,35(05):681-684.

GUI Ming-cai, et al. The effect of chronic intermittent hypoxia on blood glucose and pancreatic islets B-cell ultrastructure in rats. [J]. Journal of Chongqing Medical University 35(5):681-684(2010)
[1]桂明才,李兵,邱昌明,张涛,赵维.慢性间歇性缺氧对大鼠血糖及其胰岛B细胞超微结构的影响[J].重庆医科大学学报,2010,35(05):681-684. DOI： 10.13406/j.cnki.cyxb.2010.05.008.

GUI Ming-cai, et al. The effect of chronic intermittent hypoxia on blood glucose and pancreatic islets B-cell ultrastructure in rats. [J]. Journal of Chongqing Medical University 35(5):681-684(2010) DOI： 10.13406/j.cnki.cyxb.2010.05.008.

摘要

目的:制作可应用于常压慢性间歇性缺氧（Chronic intermittent hypoxia

CIH）研究的动物模型

探讨CIH对大鼠血糖的影响及其胰岛B细胞超微结构变化的研究。方法:大鼠分别给予空气[对照组（Unhandled

control）

UC组]、间断低氧4周（CIH组）及复氧4周[复氧组（Restore hypoxia）

RH组]处理后测定各组大鼠血糖

胰岛素

C肽

计算胰岛素抵抗指数

同时用电镜观察胰腺B细胞超微结构变化。结果:与UC组、RH组比较

CIH组的血糖升高

存在胰岛素抵抗

胰腺B细胞超微结构发生轻微缺氧损伤改变

UC组和RH组无明显改变。结论:CIH致使大鼠胰岛B细胞损伤及功能紊乱

大鼠调节血糖功能降低

同时CIH组存在胰岛素抵抗

使血糖升高

RH能使其恢复正常。

Abstract

Objective:To set up the rat model ofchronic intermittent hypoxia under normal pressure and studyits effect on the level of blood glucose and pancreatic islet B-cells

ultrstructure.Methods:Rats were respectively exposed to room air 4 weeks(unhandled control

UC)

intermittent hypoxia 4 weeks(chronic intermittent hypoxia

CIH)

intermittent hypoxia 4 weeks and then room air 4 weeks(restore hypoxia

RH).To test the fasting blood glucose of rats in each group

the fasting blood insulin and C-peptid

and then get the insulin resistance index

and observe the pancreatic islet B-cells under transmission electron microscope.Results:The level of blood glucose of the rats in the CIH group increased significantly compared with those in the UC group and RH group.There was insulin resistance and slight alteration of pancreatic islet B-cells in the CIH group

but there was no difference between UC group and RH group.Conclusion:Chronic intermittent hypoxia can lead to the pancreatic islet B-cell damage and its function disturbance

There was also insulin resistance

which causes the increased level of blood glucose of the rats in the CIH group to increase.

关键词

慢性间歇性缺氧血糖胰岛素大鼠

Keywords

chronic intermittent hypoxiablood glucoseinsulinrat

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