Effect of integr ipetal rhodiola herb on the expression of MMP-2 and TIMP-1 in rats with pulmonary fibrosis

WANG Yuan-yuan; et al

doi:10.13406/j.cnki.cyxb.2010.05.006

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Effect of integr ipetal rhodiola herb on the expression of MMP-2 and TIMP-1 in rats with pulmonary fibrosis

更新时间：2024-01-17

- Effect of integr ipetal rhodiola herb on the expression of MMP-2 and TIMP-1 in rats with pulmonary fibrosis
- Journal of Chongqing Medical University Vol. 35, Issue 5, Pages: 689-691(2010)
- 作者机构：
  
  1. 辽宁医学院附属第一医院呼吸内科
  2. 辽宁医学院附属第三医院神经内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.05.006
  CLC： R285.5
- Published：2010，
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[1]王媛媛,王庆,杨文海.红景天对肺纤维化大鼠MMP-2与TIMP-1表达关系的影响[J].重庆医科大学学报,2010,35(05):689-691.

WANG Yuan-yuan, et al. Effect of integr ipetal rhodiola herb on the expression of MMP-2 and TIMP-1 in rats with pulmonary fibrosis. [J]. Journal of Chongqing Medical University 35(5):689-691(2010)
[1]王媛媛,王庆,杨文海.红景天对肺纤维化大鼠MMP-2与TIMP-1表达关系的影响[J].重庆医科大学学报,2010,35(05):689-691. DOI： 10.13406/j.cnki.cyxb.2010.05.006.

WANG Yuan-yuan, et al. Effect of integr ipetal rhodiola herb on the expression of MMP-2 and TIMP-1 in rats with pulmonary fibrosis. [J]. Journal of Chongqing Medical University 35(5):689-691(2010) DOI： 10.13406/j.cnki.cyxb.2010.05.006.

摘要

目的:观察红景天干预肺纤维化形成的作用

初步探讨其作用机制。方法:SD大鼠45只

随机分为3组

模型组和干预组气管内注射博莱霉素诱导肺纤维化

空白组在相同条件下给予生理盐水。第2d起干预组均给予红景天灌胃

其余各组在相同条件下给予生理盐水。治疗第7d、第14d和第28d

用免疫组织化学方法观察各组鼠肺组织中基质金属蛋白酶-2（Matrix metallipro teinase-2

MMP-2）和金属蛋白酶组织抑制剂-1（Tissue inhibitor of metalloproteinase-1

TIMP-1）表达的变化。结果:对照组各视野仅见少量MMP-2、TIMP-1阳性细胞

模型组在7d、14d、28d阳性细胞明显增多

治疗组与模型组对应时间点相比阳性细胞数均有减少（P<0.01）

但仍比对照组增多（P<0.01）

差异有统计学意义。结论:红景天能抑制博莱霉素致大鼠肺纤维化模型肺组织的MMP-2、TIMP-1的合成及分泌

能在一定程度上调整MMP-2和TIMP-1的比值使其趋于平衡

可减轻博莱霉素所致大鼠的肺纤维化。

Abstract

Objective:To investigate the effect of IRH on pulmonary fibrosis and its intervention mechanism.Methods:45 sprague-dawley rats were randomly divided into three groups.The model group and the intervention group were received endotracheal injection of bleomycln to induce pulmonary fibrosis

while the control group were received endotracheal injection of saline.From the second day the intervention group IRH were injected to the stomach

while the other two groups were injected saline instead.On the 7th day

14th day and 28th day the lungs were isolated.The expression of MMP-2 and TIMP-1 was detected by immunohistochemical method respectively.Results:There was only a very weak expression of MMP-2 and TIMP-1 in the control group

there was significantly higher level in model group compared with control group on the 7th day

14th day and 28th day.The IRH group was significantly lower than the model group with the same time points

though it was also obviously higher than the control group all over the period(P<0.01).the difference has statistical significance.Conclusion:IRH may inhibit the expression of MMP-2 and TIMP-1 in the lung tissue of rat with pulmonary fibrosis

contributed to the regulation of MMP-2 and TIMP-1 balance to some extent

could alleviate bleomycin-induced pulmonary fibrosis in rats.

关键词

红景天肺纤维化基质金属蛋白酶-2组织金属蛋白酶抑制剂-1细胞外基质

Keywords

Integripetal rhodiola herbpulmonary fibrosisMatrix metallipro teinase-2(MMP-2)Tissue inhibitor of metalloproteinase-1(TIMP-1)Extracellular matrix(ECM)

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Related Institution

Department of Pulmonary Diseases,College of Clinical Medicine,Chongqing Medical University

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Department of Respirology, Zhongnan Hospital of Wuhan University

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Department of Pathophysiology,Guiyang Medical College

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