Objective:To probe the expression of Fragile histidine triad(FHIT)and p21 protein in Vulvar Condyloma acuminatum(VCA) and vulvar intraepithelial neoplasia(VIN).Methods:Immunohistochemistry was used to detect FHIT and p21 expression in 51 cases of VCA

39 cases of VIN and 20 cases of normal vulvar epithelium.Results:The positive rate of FHIT in VCA and VINⅠ～Ⅱ、VINⅢwas obviously lower than which in normal tissue(P=0.000 1);there was no statistic significance in the positive rate of FHIT expression between VINⅢand VCA(P=0.592);the positive rate of p21 in normal vulva

VIN and VCA has statistic significance;there was no statistic significance in the positive rate of p21 expression between VIN and VCA(P=0.793).Conclusion:(1)FHIT and p21 expression are associated with the development and progression of VCA and VIN(.2)The abnormality of FHIT gene is a early event in the development and progression of vulvar cancer.