Objective:To find out the clinic characteristics of congenital syphilis(CS)

to reduce the possibility of misdiagnosis.Methods:Fifty-five(aged at hedyanhour to three years)cases were analyzed the clinic manifestation retrospectively during 1999 to 2008.Results:There were 33 male and 22 female.of 55 cases

only 5 were diagnosed as CS at the beginning of entry hospital and the rest were misdiagnosed.The main complain showed 27 cases with mucocutaneous lesion(papula

papulopustule

bleb

desquamation)

26 with jaundice

32 with hepatomegaly

14 with splenomegaly

12 with tachypnea

6 with osteomyolitis

20 with nose problem(rhinocleisis

epistaxis

rhinorrhea)

7 with congenital deformity

5 with hemorrhage

4 with abdominal distension

1 with abdominal pain

2 with vomiting

2 with edema

1 with tic

1 with bad cry.Conclusion:In most newborns and infants

the onset of CP is heralded by nonspecific signs which involved multi-system.The rate of misdiagnosed for CP could be beyond 90%.