Expression and significance of bcl-2 and vascular endothelial growth factor in nephroblastoma

CHEN Jian; et al

doi:10.13406/j.cnki.cyxb.2010.04.035

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Expression and significance of bcl-2 and vascular endothelial growth factor in nephroblastoma

更新时间：2024-01-17

- Expression and significance of bcl-2 and vascular endothelial growth factor in nephroblastoma
- Journal of Chongqing Medical University Vol. 35, Issue 4, Pages: 501-503(2010)
- 作者机构：
  
  1. 兰州大学第一医院小儿外科
  2. 兰州大学第一医院病理科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.04.035
  CLC： R737.11
- Published：2010，
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[1]陈健,高明太,蒋敏,赵成基,刘登瑞,赵玉元.血管内皮生长因子和bcl-2在肾母细胞瘤中的表达及意义[J].重庆医科大学学报,2010,35(04):501-503.

CHEN Jian, et al. Expression and significance of bcl-2 and vascular endothelial growth factor in nephroblastoma. [J]. Journal of Chongqing Medical University 35(4):501-503(2010)
[1]陈健,高明太,蒋敏,赵成基,刘登瑞,赵玉元.血管内皮生长因子和bcl-2在肾母细胞瘤中的表达及意义[J].重庆医科大学学报,2010,35(04):501-503. DOI： 10.13406/j.cnki.cyxb.2010.04.035.

CHEN Jian, et al. Expression and significance of bcl-2 and vascular endothelial growth factor in nephroblastoma. [J]. Journal of Chongqing Medical University 35(4):501-503(2010) DOI： 10.13406/j.cnki.cyxb.2010.04.035.

摘要

目的:探讨细胞凋亡抑制基因B-淋巴瘤细胞-2（B-cell lymphoma/leuke mia-2

bcl-2）和血管内皮生长因子（Vascular endothelial growth factor

VEGF）在肾母细胞瘤中的表达及其相互关系。方法:用免疫组织化学和原位杂交方法研究bcl-2和VEGF蛋白及mRNA在17例肾母细胞瘤和7例瘤旁正常肾组织的表达。结果:bcl-2蛋白在肾母细胞瘤组织中的表达（82.4%）高于瘤旁正常肾组织（28.5%）;VEGF蛋白在肾母细胞瘤组织中的表达（58.8%）高于瘤旁正常肾组织（14.3%）;bcl-2 mRNA和VEGF mRNA在肾母细胞瘤的表达率分别为88.2%和82.4%;bcl-2和VEGF的表达之间存在正相关关系（rs=0.633

P<0.01）。结论:bcl-2和VEGF在小儿肾母细胞瘤发生发展中起重要作用。

Abstract

Objective:To study the expression of vascular endothelial growth factor(VEGF)and B-cell lymphoma/leuke mia-2(bcl-2) in nephroblastoma and to evaluate the relationship between VEGF and bcl-2.Methods:With mouse anti-human VEGF and bcl-2 monoclonal antibody

immunohistochemistry was used to examine 6)the expression of VEGF protein and bcl-2 protein in 17 cases of nephroblastoma and 7 cases of normal tissue as contrast.VEGF mRNA and bcl-2 mRNA expression was examined by in situ hybridization.Results:The positive expressions of bcl-2 protein in nephroblastoma(82.4%)were significantly higher than those in normal tissues(28.5%).The positive expressions of VEGF protein in nephroblastoma(58.8%)were significantly higher than those in normal tissues(14.3%).The rate of bcl-2

VEGF mRNA in nephroblastoma was 88.2%

82.4%

respectively.The expression of bcl-2

VEGF mRNA was increased significantly in nephroblastoma compare with control.VEGF expression and bcl-2 in nephroblastoma were positively related(rs=0.633

P<0.01).Conclusion:The expression of bcl-2 and VEGF plays an important role in the oncogenesis and development of nephroblastoma.

关键词

肾母细胞瘤bcl-2血管内皮生长因子（VEGF）

Keywords

NephroblastomaB-cell lymphoma/leuke mia-2(bcl-2)Vascular endothelial growth factor

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