Expression of RHAMM gene and TPX2 gene in esophageal squamous carcinoma and its clinical significance

MAO Ning; et al

doi:10.13406/j.cnki.cyxb.2010.04.032

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Expression of RHAMM gene and TPX2 gene in esophageal squamous carcinoma and its clinical significance

更新时间：2024-01-17

- Expression of RHAMM gene and TPX2 gene in esophageal squamous carcinoma and its clinical significance
- Journal of Chongqing Medical University Vol. 35, Issue 4, Pages: 557-560(2010)
- 作者机构：
  
  1. 重庆医科大学附属第一医院心胸外科
  2. 重庆市第二人民医院心胸外科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.04.032
  CLC： R735.1
- Published：2010，
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[1]毛宁,向小勇,陈力,沈学远,洪斌.食管鳞癌组织中RHAMM和TPX2基因的表达及临床意义的研究[J].重庆医科大学学报,2010,35(04):557-560.

MAO Ning, et al. Expression of RHAMM gene and TPX2 gene in esophageal squamous carcinoma and its clinical significance. [J]. Journal of Chongqing Medical University 35(4):557-560(2010)
[1]毛宁,向小勇,陈力,沈学远,洪斌.食管鳞癌组织中RHAMM和TPX2基因的表达及临床意义的研究[J].重庆医科大学学报,2010,35(04):557-560. DOI： 10.13406/j.cnki.cyxb.2010.04.032.

MAO Ning, et al. Expression of RHAMM gene and TPX2 gene in esophageal squamous carcinoma and its clinical significance. [J]. Journal of Chongqing Medical University 35(4):557-560(2010) DOI： 10.13406/j.cnki.cyxb.2010.04.032.

摘要

目的:探讨透明质酸介导的细胞游走受体（Receptor for hyaluronan-mediated motility

RHAMM）和Xklp2靶蛋白（Targetingprotein for Xklp2

TPX2）基因在食管鳞癌中的表达及其与临床病理因素的关系。方法:采用逆转录聚合酶链反应技术

检测40例食管鳞癌肿瘤组织、癌旁组织、相应食管正常黏膜组织中RHAMM和TPX2基因的表达。结果:RHAMM mRNA在食管鳞癌组织中的表达（65.0%）显著高于癌旁组织（37.5%）及正常黏膜组织（22.5%）

且与是否发生淋巴结转移有关（P<0.01）;TPX2 mRNA在食管鳞癌组织中的表达（75.0%）也显著高于癌旁组织（47.5%）及正常黏膜组织（40.0%）

与是否发生淋巴结转移及分化程度有关（P<0.05）;RHAMM mRNA及TPX2 mRNA在食管鳞癌组织中的阳性表达具有相关性（P<0.01

r=0.39）。结论:RHAMM及TPX2基因可能共同参与了食管鳞癌的发生、进展及转移。

Abstract

Objective:Toinvestigate the expression of RHAMMgene and TPX2 gene in esophageal squamous cell carcinoma(ESCC)and their relationships with clinicopathological factors.Methods:The expression of RHAMM gene and TPX2 gene were detected by reverse transcriptase polymerase chain reaction(RT-PCR)in ESCC tissues

para-cancer tissues

and matched esophageal normal mucosa tissues of 40 patients.Results:The positive expressions of RHAMM mRNA in ESCC tissues(65.0%)were significantly higher than those in para-cancer tissues(37.5%)and esophageal normal mucosa tissues(22.5%).Significant relationship was observed between positive expression of RHAMM mRNA and lymphnode metastasis(P<0.01).The positive expressions of TPX2 mRNA in ESCC tissues(75.0%) were also significantly higher than those in para-cancer tissues(47.5%)and esophageal normal mucosa tissues(40.0%).Significant relationship was observed between positive expression of TPX2 mRNA and lymphnode metastasis or degrees of differentiation(P<0.05).A significant association was found between the mRNA expression of TPX2 and RHAMM(P<0.01

r=0.39).Conclusion:High expression of RHAMM gene together with TPX2 gene might play important roles in the tumorigenesis and metastasis of ESCC.

关键词

RHAMM基因TPX2基因食管鳞癌RT-PCR

Keywords

RHAMMgeneTPX2 geneEsophageal squamous carcinomaRT-PCR

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