Relationship between Parkinson’s disease and risk factors of cerebrovascular disease

GAO Jie; et al

doi:10.13406/j.cnki.cyxb.2010.04.028

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Relationship between Parkinson’s disease and risk factors of cerebrovascular disease

更新时间：2024-01-17

- Relationship between Parkinson’s disease and risk factors of cerebrovascular disease
- Journal of Chongqing Medical University Vol. 35, Issue 4, Pages: 561-563(2010)
- 作者机构：
  
  1. 重庆医科大学附属第一医院神经内科
  2. 重庆医科大学附属永川医院神经内科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.04.028
  CLC： R742.5
- Published：2010，
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[1]高洁,王法祥,李志伟,彭国光.促脑血管疾病危险因素与帕金森病相关性研究[J].重庆医科大学学报,2010,35(04):561-563.

GAO Jie, et al. Relationship between Parkinson’s disease and risk factors of cerebrovascular disease. [J]. Journal of Chongqing Medical University 35(4):561-563(2010)
[1]高洁,王法祥,李志伟,彭国光.促脑血管疾病危险因素与帕金森病相关性研究[J].重庆医科大学学报,2010,35(04):561-563. DOI： 10.13406/j.cnki.cyxb.2010.04.028.

GAO Jie, et al. Relationship between Parkinson’s disease and risk factors of cerebrovascular disease. [J]. Journal of Chongqing Medical University 35(4):561-563(2010) DOI： 10.13406/j.cnki.cyxb.2010.04.028.

摘要

目的:探讨促脑血管疾病的一些常见危险因素与帕金森病（Parkinson’s disease

PD）之间的关系。方法:对在重庆医科大学附属第一医院就诊的PD患者及健康体检者抽血检测血糖、低密度脂蛋白胆固醇（Low density lipoprotein cholesterol

LDL-C）及同型半胱氨酸（Homocysteic acid

Hcy）

同时行颈动脉彩超了解颈总动脉内膜中层厚度（Intima-media thickness of carotid artery

IMT）

对PD患者进行帕金森病统一评定量表（Unified Parkinson’s disease rating scale

UPDRS）评分。对PD组和对照组检查结果进行统计学分析

并将可能与PD发病有关的因素纳入相关分析。结果:PD组血糖水平高于对照组（P<0.05）;Hcy水平高于对照组（P<0.01）;PD组LDL-C水平低于对照组（P<0.05）;IMT值小于对照组（P<0.001）。Spearman相关分析显示Hcy与PD发病呈正相关

LDL-C、IMT与PD发病呈负相关

血糖与PD发病无明显相关性。结论:本实验结果提示高Hcy是PD发病的危险因素;实验证实PD病人LDL-C、IMT明显低于对照组

提示患动脉粥样硬化的几率相对较小。

Abstract

Objective:To investigate the relationship between some common risk factors of the cerebralvascular diseases and PD.Methods:Case-control study was carried out.Blood glucose

low density lipoprotein cholesterol(LDL-C)and homocysteic acid(Hcy) levels were detected by routine methods.The intima-media thickness(IMT)of carotid artery was measured by color Doppler ultrasound.The PD patients were graded by Unified Parkinson’s Disease Rating Scale(UPDRS).Results:The blood glucose and Hcy in PD patients were higher than that in control group

and the LDL-C

IMT of carotid artery in PD were lower than that in control group.The Hcy was positively related to risk of PD

while IMT of carotid artery and LDL-C were negatively related to risk of PD by Spearman analysis.Conclusion:The Hcy level is a risk factor of PD.The LDL-C and IMT of carotid artery in PD patients were lower than that in control group

which suggests that the probability of PD patients who suffer from atherosclerosis is small.

关键词

帕金森病颈动脉内膜中层厚度血糖低密度脂蛋白胆固醇同型半胱氨酸相关性

Keywords

Parkinson’s diseaseIMTblood glucoseLDL-CHcyRelationship

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