Analysis of prenatal screening 1648 cases in mid-pregnant women

Zhang Yu-qin

doi:10.13406/j.cnki.cyxb.2010.04.023

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Analysis of prenatal screening 1648 cases in mid-pregnant women

更新时间：2024-01-17

- Analysis of prenatal screening 1648 cases in mid-pregnant women
- Journal of Chongqing Medical University Vol. 35, Issue 4, Pages: 639-640(2010)
- 作者机构：
  
  重庆市九龙坡区妇幼保健院检验科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.04.023
  CLC： R714.55
- Published：2010，
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[1]张于勤.1648例孕中期母血清产前筛查结果分析[J].重庆医科大学学报,2010,35(04):639-640.

Zhang Yu-qin. Analysis of prenatal screening 1648 cases in mid-pregnant women. [J]. Journal of Chongqing Medical University 35(4):639-640(2010)
[1]张于勤.1648例孕中期母血清产前筛查结果分析[J].重庆医科大学学报,2010,35(04):639-640. DOI： 10.13406/j.cnki.cyxb.2010.04.023.

Zhang Yu-qin. Analysis of prenatal screening 1648 cases in mid-pregnant women. [J]. Journal of Chongqing Medical University 35(4):639-640(2010) DOI： 10.13406/j.cnki.cyxb.2010.04.023.

摘要

目的:评估血清标志物甲胎蛋白（Alpha-fetoprotein

AFP）和游离绒毛膜促性腺激素（Free-βHCG）在孕中期进行先天缺陷疾病筛查的价值和作用。方法:用酶联免疫法对孕妇血清AFP和free-βHCG进行检测

并结合孕妇年龄、孕周、体重等因素

采用配套软件估算风险概率。结果:在3299例孕中期妇女中

唐氏综合征、18-三体综合征和神经管缺陷高危筛查阳性率分别为7.16%、0.61%和2.37%。经细胞遗传学分析1例确诊为唐氏综合征

另外2例经超声检查证实为神经管缺陷。结论:孕中期母血清二联（AFP

free-βHCG）检查是有效安全的产前筛查方法

有利于降低先天性缺陷婴儿的出生率。

Abstract

Objective:To assess the value and impact of screening programme in mid-pregnancy women for the congenital fet abnormality that uses the two maternal serum markers:α-fetoprotein(AFP)and freeβhuman chorionic gonadotrophin(free-βHCG) Methods:Serum screening of AFP and free-βHCG were offered to the 14～20 weeks pregnant Measuring the serum AFP and free βHCGin pregnant women with ELISA

and combined with other factors:age

weeks of pregnancy

weight

etc.Measuring the high ri rate with special software.Results:Within 1 648 cases of women in the mid-pregnancy

Down’s syndrom

18-trisomysyndrome an neural tube defect high risk rates in screen were 7.16%

0.61%and 2.37%respectively.1 case was confirm the Down’s syndrome analysis of cytogenetics

another 2 cases was diagnosed neural tube defect via ultrasonography.Conclusion:the second trimester doub test would be effective and safe screening strategies and could be used to decrease natality of congenital fetal malformation

关键词

唐氏综合征神经管缺陷18-三体综合征产前筛查

Keywords

Down’s syndromeNerual tube defect18-trisomysyndromePrenatal screening

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Related Institution

Special Care Ward,Children’s Hospital,Chongqing Medical University

重庆医科大学附属儿童医院临床分子医学中心

Maternal and Infant Center，Chongqing Health Center for Women and Children

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