Membrane glycoprotein CD36 deficiency promotes insulin resistance in C57BL/6 mice

CHEN Xian; et al

doi:10.13406/j.cnki.cyxb.2010.04.016

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Membrane glycoprotein CD36 deficiency promotes insulin resistance in C57BL/6 mice

更新时间：2024-01-17

- Membrane glycoprotein CD36 deficiency promotes insulin resistance in C57BL/6 mice
- Journal of Chongqing Medical University Vol. 35, Issue 4, Pages: 485-487(2010)
- 作者机构：
  
  1. 重庆医科大学附属第一医院临床研究中心
  2. 重庆医科大学附属第一医院
  3. 重庆医科大学脂质代谢研究中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.04.016
  CLC： R587.1
- Published：2010，
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[1]陈显,柳青,雷寒,赵蕾,刘宏,陈压西,阮雄中.膜糖蛋白CD36缺失对小鼠胰岛素抵抗的影响[J].重庆医科大学学报,2010,35(04):485-487.

CHEN Xian, et al. Membrane glycoprotein CD36 deficiency promotes insulin resistance in C57BL/6 mice. [J]. Journal of Chongqing Medical University 35(4):485-487(2010)
[1]陈显,柳青,雷寒,赵蕾,刘宏,陈压西,阮雄中.膜糖蛋白CD36缺失对小鼠胰岛素抵抗的影响[J].重庆医科大学学报,2010,35(04):485-487. DOI： 10.13406/j.cnki.cyxb.2010.04.016.

CHEN Xian, et al. Membrane glycoprotein CD36 deficiency promotes insulin resistance in C57BL/6 mice. [J]. Journal of Chongqing Medical University 35(4):485-487(2010) DOI： 10.13406/j.cnki.cyxb.2010.04.016.

摘要

目的:研究膜糖蛋白CD36缺失对C57BL/6小鼠胰岛素抵抗（Insulin resistance

IR）的影响。方法:14周高脂饮食喂养的野生型C57BL/6小鼠和CD36基因敲除（CD36KO）小鼠

每组7只

分别进行糖耐量

胰岛素耐量和胰岛素释放试验

以及血清中甘油三酯（Triglyceride

TG）和游离脂肪酸（Free fat acid

FFA）的测定。结果:与野生型C57BL/6相比

CD36KO小鼠血糖水平增高

糖耐量实验异常

胰岛素释放曲线延迟

血清中TG（（80±28.74）vs（36±18.88）mg/dl

P<0.05）和FFA（（13.61±1.08）vs（0.8±0.06）mmol/L

P<0.05）水平增加。结论:CD36缺失可以促进小鼠IR。

Abstract

Objective:To explore whether CD36 deficiency promotes insulin resistancein the C57BL/6 mice.Methods:Micewerefedwith a high-fat die(tn=7)for 14 weeks.Intravenous glucose tolerance tests

insulin release and tolerance tests were performed.Triglyceride and free fat acid levels in serum were measured.Results:Compared with the C57BL/6 mice

blood levels of glucose

insulin

triglyceride and free fatty acid were increased in the CD36 knockout mice.Conclusion:The CD36 deficiency indeed promotes insulin resistance in the C57BL/6 mice.

关键词

CD36C57BL/6小鼠CD36基因敲除小鼠胰岛素抵抗

Keywords

CD36C57BL/6 miceCD36 knockout miceinsulin resistance

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