Study of association between ApoB/ApoA1 ratio and insulin resistance

JIANG Yuan-juan; et al

doi:10.13406/j.cnki.cyxb.2010.04.015

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Study of association between ApoB/ApoA1 ratio and insulin resistance

更新时间：2024-01-17

- Study of association between ApoB/ApoA1 ratio and insulin resistance
- Journal of Chongqing Medical University Vol. 35, Issue 4, Pages: 575-578(2010)
- 作者机构：
  
  1. 重庆医科大学附属第一医院内分泌科
  2. 重庆医科大学附属第一医院体检中心
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.04.015
  CLC： R587
- Published：2010，
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[1]蒋袁娟,李启富,罗蓉,成丹,刘洲君,钟立,王邦琼,程庆丰,王永红.ApoB/ApoA1比值与胰岛素抵抗的相关性研究[J].重庆医科大学学报,2010,35(04):575-578.

JIANG Yuan-juan, et al. Study of association between ApoB/ApoA1 ratio and insulin resistance. [J]. Journal of Chongqing Medical University 35(4):575-578(2010)
[1]蒋袁娟,李启富,罗蓉,成丹,刘洲君,钟立,王邦琼,程庆丰,王永红.ApoB/ApoA1比值与胰岛素抵抗的相关性研究[J].重庆医科大学学报,2010,35(04):575-578. DOI： 10.13406/j.cnki.cyxb.2010.04.015.

JIANG Yuan-juan, et al. Study of association between ApoB/ApoA1 ratio and insulin resistance. [J]. Journal of Chongqing Medical University 35(4):575-578(2010) DOI： 10.13406/j.cnki.cyxb.2010.04.015.

摘要

目的:探讨载脂蛋白B（ApoB）/载脂蛋白A1（ApoA1）比值与胰岛素抵抗（Insulin Resistance

IR）的关系。方法:纳入673例重庆地区成年人

测定体重、身高、血压、腰围、空腹血浆葡萄糖（Fastingplasma glucose

FPG）、空腹血清胰岛素（Fasting serum insulin

FINS）及血脂等

计算ApoB/ApoA1比值、体重指数（Bodymassindex

BMI）及胰岛素抵抗指数（Homa-IR）。根据ApoB/ApoA1的四分位值将人群分为4组

用Logistic回归分析ApoB/ApoA1值与IR的关系。结果:与非胰岛素抵抗（Non-insulinresistance）者相比

IR人群的年龄、BMI、收缩压、舒张压、FPG、FINS、TG、LDL-c水平及ApoB/ApoA1比值均显著增高

而HDL-c水平降低（P<0.05）;随ApoB/ApoA1值增高

HomaIR值逐渐增高（P<0.001）;ApoB/ApoA1值最高组（上四分位组）发生IR的风险是最低组（下四分位组）的2.586倍（P=0.001）。结论:ApoB/ApoA1比值与IR密切相关

ApoB/ApoA1比值增高是IR发生的重要标志。

Abstract

Objective:To assess if the ratio of ApoB/ApoA1 is related to insulin resistance.Methods:673 adults living in Chongqing were enrolled.Weight

height

blood pressure

waist circumferences

fasting plasma glucose(FPG)

fasting serum insulin(FINS)and lipids were measured.ApoB/ApoA1 ratio

BMI and insulin resistance index(Homa-IR)were calculated.Subjects were divided into four groups according to the quartiles of ApoB/ApoA1 ratio.Logistic regression was used to estimate the relation between ApoB/ApoA1 ratio and insulin resistance.Results:Compared with the non-insulin resistant group

the insulin resistant group is older and has on average greater mean values for BMI

systolic and diastolic blood pressure

fasting plasma glucose

triglycerides

LDL-cholesterol

and ApoB/ApoA1 ratio.In contrast

insulin resistant subjects has significantly lower HDL-cholesterol than insulin sensitive subjects(P<0.05).Homeostasis model assessment increased significantly as ApoB/ApoA1 ratio increased(P<0.001).Compared with the lowest quartile of ApoB/ApoA1 ratio

the highest quartile of ApoB/ApoA1 ratio is more likely to get IR

and the risk increased 2.586 times(P=0.001).Conclusion:ApoB/ApoA1 ratio is strongly associated with insulin resistance(IR)

and a high ApoB/ApoA1 ratio is a valuable marker of IR.

关键词

ApoB/ApoA1比值胰岛素抵抗

Keywords

ApoB/ApoA1 ratioinsulin resistance

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