The therapeutic effects comparison between one and two hemoperfusion in treatment of chronic hepatitis with hyperbilirubinemia

LANG Qing; et al

doi:10.13406/j.cnki.cyxb.2010.04.014

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The therapeutic effects comparison between one and two hemoperfusion in treatment of chronic hepatitis with hyperbilirubinemia

更新时间：2024-01-17

- The therapeutic effects comparison between one and two hemoperfusion in treatment of chronic hepatitis with hyperbilirubinemia
- Journal of Chongqing Medical University Vol. 35, Issue 4, Pages: 597-599(2010)
- 作者机构：
  
  1. 重庆医科大学附属第二医院感染科
  2. 杭州市第六人民医院感染科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.2010.04.014
  CLC： R575.1
- Published：2010，
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[1]郎清,张丽旦,戚敬虎,钱克莉,石小枫.血液灌流1次与2次治疗慢性肝炎高胆红素患者的疗效比较[J].重庆医科大学学报,2010,35(04):597-599.

LANG Qing, et al. The therapeutic effects comparison between one and two hemoperfusion in treatment of chronic hepatitis with hyperbilirubinemia. [J]. Journal of Chongqing Medical University 35(4):597-599(2010)
[1]郎清,张丽旦,戚敬虎,钱克莉,石小枫.血液灌流1次与2次治疗慢性肝炎高胆红素患者的疗效比较[J].重庆医科大学学报,2010,35(04):597-599. DOI： 10.13406/j.cnki.cyxb.2010.04.014.

LANG Qing, et al. The therapeutic effects comparison between one and two hemoperfusion in treatment of chronic hepatitis with hyperbilirubinemia. [J]. Journal of Chongqing Medical University 35(4):597-599(2010) DOI： 10.13406/j.cnki.cyxb.2010.04.014.

摘要

目的:探讨利用血液灌流（Hemoperfusion

HP）1次和2次治疗慢性肝炎高胆红素患者的临床疗效。方法:采用回顾性分析方法

收集27例血液灌流1次和41例血液灌流2次的慢性肝炎高胆红素患者的临床资料

观察并对比分析组之间治疗前后肝功能、凝血酶原时间、生化等指标。结果:HP2组与HP1组对比分析得出

HP2组较HP1组患者胆红素和转氨酶有明显的降低（P<0.05）

但红细胞和血红蛋白也有显著降低（P<0.05）

其余各指标两组间无明显差异（P>0.05）;2组的血钾均有明显的升高。结论:2次HP更能有效吸附和降低慢性肝炎患者体内的胆红素和转氨酶

是治疗高胆红素血症患者的有效手段。

Abstract

Objective:To investigate the clinical efficacy between one and two hemoperfusion in treatment of chronic hepatitis with hyperbilirubinemia.Methods:The clinical data of 68 chronic hepatitis patients with hyperbilirubinemia were reviewed restropectively.27 patients were treated with one hemoperfusion(HP1)and 41 patients were treated with two hemoperfusion(HP2).The liver function

prothrombin time activity

biochemical indicators before and after hemoperfusion in the two groups were compared and analyzed.Results:After two hemoperfusion treatment.

Compared with HP1

the levels of bilirubin and transaminase were decreased significantly(P<0.05)but the erythrocyte and hemoglobin were also decreased significantly(P<0.05)in HP2 treatment group(434.44± 163.28)v(s480.48±168.31)

(104.85±142.85)v(s176.77±132.61)

(3.30±0.58)v(s3.58±0.48)

(95.49±15.31)v(s108.93± 15.66)

other indicators had no significanc(P>0.05).Conclusions:Two hemoperfusion treatment can more effectively make bilirubin and transaminase removed from patients of chronic hepatitis with hyperbilirubinemia

so two hemoperfusion was safe and effective treatment for patients with hyperbilirubinemia.

关键词

血液灌流慢性肝炎高胆红素血症疗效

Keywords

hemoperfusionChronic hepatitishyperbilirubinemiacurative effect

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